Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/36944
Título: | Chitosan/bioactive glass nanoparticles scaffolds with shape memory properties |
Autor(es): | Correia, Cristina Leite, Álvaro J. Mano, J. F. |
Palavras-chave: | Bioactive glass nanoparticles Bioactivity Biomimetic Chitosan Hydromechanical cyclic test Shape memory |
Data: | 2015 |
Editora: | Elsevier 1 |
Revista: | Carbohydrate Polymers |
Citação: | Correia C. O., Leite A. J., Mano J. F. Chitosan/bioactive glass nanoparticles scaffolds with shape memory properties, Carbohydrate Polymers, Vol. 123, pp. 39-45, doi:10.1016/j.carbpol.2014.12.076, 2015 |
Resumo(s): | We propose a combination of chitosan (CHT) with bioactive glass nanoparticles (BG-NPs) in order to produce CHT/BG-NPs scaffolds that combine the shape memory properties of chitosan and the biomineralization ability of BG-NPs for applications in bone regeneration. The addition of BG-NPs prepared by a solâ gel route to the CHT polymeric matrix improved the bioactivity of the nanocomposite scaffold, as seen by the precipitation of bone-like apatite layer upon immersion in simulated body fluid (SBF). Shape memory tests were carried out while the samples were immersed in varying compositions of water/ethanol mixtures. Dehydration with ethanol enables to fix a temporary shape of a deformed scaffold that recovers the initial geometry upon water uptake. The scaffolds present good shape memory properties characterized by a recovery ratio of 87.5% for CHT and 89.9% for CHT/BG-NPs and a fixity ratio of 97.2% for CHT and 98.2% for CHT/BG-NPs (for 30% compressive deformation). The applicability of such structures was demonstrated by a good geometrical accommodation of a previously compressed scaffold in a bone defect. The results indicate that the developed CHT/BG-NPs nanocomposite scaffolds have potential for being applied in bone tissue engineering. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/36944 |
DOI: | 10.1016/j.carbpol.2014.12.076 |
ISSN: | 0144-8617 |
Versão da editora: | http://dx.doi.org/10.1016/j.carbpol.2014.12.076 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18322-1-s2.0-S0144861715000211-main.pdf Acesso restrito! | 1,63 MB | Adobe PDF | Ver/Abrir |