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https://hdl.handle.net/1822/36944
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Campo DC | Valor | Idioma |
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dc.contributor.author | Correia, Cristina | por |
dc.contributor.author | Leite, Álvaro J. | por |
dc.contributor.author | Mano, J. F. | por |
dc.date.accessioned | 2015-09-09T13:46:50Z | - |
dc.date.available | 2015-09-09T13:46:50Z | - |
dc.date.issued | 2015 | - |
dc.date.submitted | 2014 | - |
dc.identifier.citation | Correia C. O., Leite A. J., Mano J. F. Chitosan/bioactive glass nanoparticles scaffolds with shape memory properties, Carbohydrate Polymers, Vol. 123, pp. 39-45, doi:10.1016/j.carbpol.2014.12.076, 2015 | por |
dc.identifier.issn | 0144-8617 | por |
dc.identifier.uri | https://hdl.handle.net/1822/36944 | - |
dc.description.abstract | We propose a combination of chitosan (CHT) with bioactive glass nanoparticles (BG-NPs) in order to produce CHT/BG-NPs scaffolds that combine the shape memory properties of chitosan and the biomineralization ability of BG-NPs for applications in bone regeneration. The addition of BG-NPs prepared by a solâ gel route to the CHT polymeric matrix improved the bioactivity of the nanocomposite scaffold, as seen by the precipitation of bone-like apatite layer upon immersion in simulated body fluid (SBF). Shape memory tests were carried out while the samples were immersed in varying compositions of water/ethanol mixtures. Dehydration with ethanol enables to fix a temporary shape of a deformed scaffold that recovers the initial geometry upon water uptake. The scaffolds present good shape memory properties characterized by a recovery ratio of 87.5% for CHT and 89.9% for CHT/BG-NPs and a fixity ratio of 97.2% for CHT and 98.2% for CHT/BG-NPs (for 30% compressive deformation). The applicability of such structures was demonstrated by a good geometrical accommodation of a previously compressed scaffold in a bone defect. The results indicate that the developed CHT/BG-NPs nanocomposite scaffolds have potential for being applied in bone tissue engineering. | por |
dc.description.sponsorship | This work was supported by the Portuguese Foundation for Science and Technology Foundation (FCT) through the project PTDC/FIS/115048/2009 and the doctoral Grant SFRH/BD/73174/2010 of Alvaro J. Leite. We also acknowledge Dr. Ana Rita Duarte for her contribution to the micro-CT analysis. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | restrictedAccess | por |
dc.subject | Bioactive glass nanoparticles | por |
dc.subject | Bioactivity | por |
dc.subject | Biomimetic | por |
dc.subject | Chitosan | por |
dc.subject | Hydromechanical cyclic test | por |
dc.subject | Shape memory | por |
dc.title | Chitosan/bioactive glass nanoparticles scaffolds with shape memory properties | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.carbpol.2014.12.076 | por |
dc.comments | http://www.3bs.uminho.pt/node/18322 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 39 | por |
oaire.citationEndPage | 45 | por |
oaire.citationTitle | Carbohydrate Polymers | por |
oaire.citationVolume | 123 | por |
dc.date.updated | 2015-08-05T14:44:21Z | - |
dc.identifier.doi | 10.1016/j.carbpol.2014.12.076 | por |
dc.identifier.pmid | 25843832 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Carbohydrate Polymers | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
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18322-1-s2.0-S0144861715000211-main.pdf Acesso restrito! | 1,63 MB | Adobe PDF | Ver/Abrir |