Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/24084
Título: | Long non-coding RNAs and cancer: a new frontier of translational research? |
Autor(es): | Spizzo, Riccardo Almeida, Maria Inês Colombatti, A. Calin, George A. |
Palavras-chave: | Long non-coding RNAs Cancer Online databases Function |
Data: | 2012 |
Editora: | Nature Publishing Group |
Revista: | Oncogene |
Resumo(s): | Tiling array and novel sequencing technologies have made available the transcription profile of the entire human genome. However, the extent of transcription and the function of genetic elements that occur outside of protein-coding genes, particularly those involved in disease, are still a matter of debate. In this review, we focus on long non-coding RNAs (lncRNAs) that are involved in cancer. We define lncRNAs and present a cancer-oriented list of lncRNAs, list some tools (for example, public databases) that classify lncRNAs or that scan genome spans of interest to find whether known lncRNAs reside there, and describe some of the functions of lncRNAs and the possible genetic mechanisms that underlie lncRNA expression changes in cancer, as well as current and potential future applications of lncRNA research in the treatment of cancer. |
Tipo: | Artigo |
Descrição: | Author manuscript |
URI: | https://hdl.handle.net/1822/24084 |
DOI: | 10.1038/onc.2011.621 |
ISSN: | 0950-9232 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Spizzo R_Oncogene 2012.pdf | Versão posprint | 629,28 kB | Adobe PDF | Ver/Abrir |