Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/20647
Título: | Vascularization in bone tissue engineering : physiology, current strategies, major hurdles and future challenges |
Autor(es): | Santos, Marina I. Reis, R. L. |
Palavras-chave: | biomaterials bone fracture repair tissue engineering vascularization |
Data: | 2010 |
Editora: | Wiley |
Revista: | Macromolecular Bioscience |
Resumo(s): | The lack of a functional vascular supply has, to a large extent, hampered the whole range of clinical applications of ‘successful’ laboratory-based bone tissue engineering strategies. To the present, grafts have been dependent on post-implant vascularization, which jeopardizes graft integration and often leads to its failure. For this reason, the development of strategies that could effectively induce the establishment of a microcirculation in the engineered constructs has become a major goal for the tissue engineering research community. This review addresses the role and importance of the development of a vascular network in bone tissue engineering and provides an overview of the most up to date research efforts to develop such a network. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/20647 |
DOI: | 10.1002/mabi.200900107 |
ISSN: | 1616-5187 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |