Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/20647
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Santos, Marina I. | - |
dc.contributor.author | Reis, R. L. | - |
dc.date.accessioned | 2012-11-02T17:42:09Z | - |
dc.date.available | 2012-11-02T17:42:09Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1616-5187 | por |
dc.identifier.uri | https://hdl.handle.net/1822/20647 | - |
dc.description.abstract | The lack of a functional vascular supply has, to a large extent, hampered the whole range of clinical applications of ‘successful’ laboratory-based bone tissue engineering strategies. To the present, grafts have been dependent on post-implant vascularization, which jeopardizes graft integration and often leads to its failure. For this reason, the development of strategies that could effectively induce the establishment of a microcirculation in the engineered constructs has become a major goal for the tissue engineering research community. This review addresses the role and importance of the development of a vascular network in bone tissue engineering and provides an overview of the most up to date research efforts to develop such a network. | por |
dc.description.sponsorship | M. I. Santos would like to acknowledge the Portuguese Foundation for Science and Technology (FCT) for her Ph.D. grant (SFRH/BD/13428/2003). This work was partially supported by FCT through funds from POCTI and/or FEDER programs and by the European Union funded STREP Project HIPPOCRATES (NMP3-CT-2003-505758). This work was carried out under the scope of the European NoE EXPERTISSUES (NMP3-CT-2004-500283). The authors also acknowledge Gabriela A. Silva for critically reading the manuscript. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley | por |
dc.rights | openAccess | por |
dc.subject | biomaterials | por |
dc.subject | bone | por |
dc.subject | fracture repair | por |
dc.subject | tissue engineering | por |
dc.subject | vascularization | por |
dc.title | Vascularization in bone tissue engineering : physiology, current strategies, major hurdles and future challenges | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 12 | por |
oaire.citationEndPage | 27 | por |
oaire.citationIssue | 1 | por |
oaire.citationTitle | Macromolecular Bioscience | por |
oaire.citationVolume | 10 | por |
dc.identifier.doi | 10.1002/mabi.200900107 | por |
dc.identifier.pmid | 19688722 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Macromolecular Bioscience | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |