Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/13737
Título: | Bone response and mechanical strength of rabbit femoral defects filled with injectable CaP cements containing TGF-β1 loaded gelatin microparticles |
Autor(es): | Link, Dennis P. Van den Dolder, Juliette Van den Beucken, Jeroen J. Wolke, Joop G. Mikos, Antonios G. Jansen, John A. |
Palavras-chave: | Injectable CaP cement Gelatin microparticles TGF-β1 Mechanical properties Bone ingrowth |
Data: | 2008 |
Editora: | Elsevier 1 |
Revista: | Biomaterials |
Resumo(s): | This study focused at the potential of transforming growth factor β1 (TGF-β1) loaded gelatin microparticles to enhance the bone response and mechanical strength of rabbit femoral defects filled with injectable calcium phosphate (CaP)/gelatin microparticle composites. Therefore, TGF-β1 loaded composites and non-loaded controls were injected in circular defects as created in the femoral condyles of rabbits and were left in place for 4, 8 and 12 weeks. The specimens were evaluated mechanically (push-out test), and morphologically (scanning electron microscopy (SEM), histology, and histomorphometry). The results showed a gradual increase in mechanical strength with increasing implantation periods. Histological and histomorphometrical evaluation showed similar results for both composite formulations regarding histological aspect, new bone formation and bone/implant contact. However, TGF-β1 loading of the composites demonstrated a significant effect on composite degradation after twelve weeks of implantation. The results of this study showed that CaP/gelatin composites show excellent osteogenic properties and a rapid increase in mechanical strength. The addition of TGF-β1 significantly enhances the bone remodeling process. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/13737 |
ISSN: | 0142-9612 |
Versão da editora: | http://dx.doi.org/10.1016/j.biomaterials.2007.10.029 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |