Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/13737
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Link, Dennis P. | - |
dc.contributor.author | Van den Dolder, Juliette | - |
dc.contributor.author | Van den Beucken, Jeroen J. | - |
dc.contributor.author | Wolke, Joop G. | - |
dc.contributor.author | Mikos, Antonios G. | - |
dc.contributor.author | Jansen, John A. | - |
dc.date.accessioned | 2011-09-29T09:38:53Z | - |
dc.date.available | 2011-09-29T09:38:53Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0142-9612 | por |
dc.identifier.uri | https://hdl.handle.net/1822/13737 | - |
dc.description.abstract | This study focused at the potential of transforming growth factor β1 (TGF-β1) loaded gelatin microparticles to enhance the bone response and mechanical strength of rabbit femoral defects filled with injectable calcium phosphate (CaP)/gelatin microparticle composites. Therefore, TGF-β1 loaded composites and non-loaded controls were injected in circular defects as created in the femoral condyles of rabbits and were left in place for 4, 8 and 12 weeks. The specimens were evaluated mechanically (push-out test), and morphologically (scanning electron microscopy (SEM), histology, and histomorphometry). The results showed a gradual increase in mechanical strength with increasing implantation periods. Histological and histomorphometrical evaluation showed similar results for both composite formulations regarding histological aspect, new bone formation and bone/implant contact. However, TGF-β1 loading of the composites demonstrated a significant effect on composite degradation after twelve weeks of implantation. The results of this study showed that CaP/gelatin composites show excellent osteogenic properties and a rapid increase in mechanical strength. The addition of TGF-β1 significantly enhances the bone remodeling process. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | - |
dc.rights | openAccess | por |
dc.subject | Injectable CaP cement | por |
dc.subject | Gelatin microparticles | por |
dc.subject | TGF-β1 | por |
dc.subject | Mechanical properties | por |
dc.subject | Bone ingrowth | por |
dc.title | Bone response and mechanical strength of rabbit femoral defects filled with injectable CaP cements containing TGF-β1 loaded gelatin microparticles | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.biomaterials.2007.10.029 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 675 | por |
oaire.citationEndPage | 682 | por |
oaire.citationTitle | Biomaterials | por |
oaire.citationVolume | 29 | por |
sdum.journal | Biomaterials | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |