Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/13597
Título: | Nanoliposomes for encapsulation and delivery of the potential antitumoral methyl 6-methoxy-3-(4-methoxyphenyl)-1H-indole-2-carboxylate |
Autor(es): | Abreu, Ana S. Castanheira, Elisabete M. S. Queiroz, Maria João R. P. Ferreira, Paula M. T. Silva, Luís A. Vale Pinto, Eugénia |
Palavras-chave: | Nanoliposomes Antitumoral drugs Fluorescence Dialysis |
Data: | Ago-2011 |
Editora: | SpringerOpen |
Revista: | Nanoscale Research Letters |
Resumo(s): | A potential antitumoral fluorescent indole derivative, methyl 6-methoxy-3-(4-methoxyphenyl)-1H-indole-2-carboxylate, was evaluated for the in vitro cell growth inhibition on three human tumor cell lines, MCF-7 (breast adenocarcinoma), A375-C5 (melanoma), and NCI-H460 (non-small cell lung cancer), after a continuous exposure of 48 h, exhibiting very low GI50 values for all the cell lines tested (0.25 to 0.33 µM). This compound was encapsulated in different nanosized liposome formulations, containing egg lecithin (Egg-PC), dipalmitoyl phosphatidylcholine (DPPC), dipalmitoyl phosphatidylglycerol (DPPG), DSPC, cholesterol, dihexadecyl phosphate, and DSPE-PEG. Dynamic light scattering measurements showed that nanoliposomes with the encapsulated compound are generally monodisperse and with hydrodynamic diameters lower than 120 nm, good stability and zeta potential values lower than −18 mV. Dialysis experiments allowed to monitor compound diffusion through the lipid membrane, from DPPC/DPPG donor liposomes to NBD-labelled lipid/DPPC/DPPG acceptor liposomes. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/13597 |
DOI: | 10.1186/1556-276X-6-482 |
ISSN: | 1556-276X |
Versão da editora: | http://www.nanoscalereslett.com |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDF - FAMO - Artigos/Papers (with refereeing) CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Nanoscale2011_Nanoliposomes.pdf | Documento principal | 336,33 kB | Adobe PDF | Ver/Abrir |