Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/13597
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Abreu, Ana S. | - |
dc.contributor.author | Castanheira, Elisabete M. S. | - |
dc.contributor.author | Queiroz, Maria João R. P. | - |
dc.contributor.author | Ferreira, Paula M. T. | - |
dc.contributor.author | Silva, Luís A. Vale | - |
dc.contributor.author | Pinto, Eugénia | - |
dc.date.accessioned | 2011-09-15T16:57:41Z | - |
dc.date.available | 2011-09-15T16:57:41Z | - |
dc.date.issued | 2011-08 | - |
dc.identifier.issn | 1556-276X | por |
dc.identifier.uri | https://hdl.handle.net/1822/13597 | - |
dc.description.abstract | A potential antitumoral fluorescent indole derivative, methyl 6-methoxy-3-(4-methoxyphenyl)-1H-indole-2-carboxylate, was evaluated for the in vitro cell growth inhibition on three human tumor cell lines, MCF-7 (breast adenocarcinoma), A375-C5 (melanoma), and NCI-H460 (non-small cell lung cancer), after a continuous exposure of 48 h, exhibiting very low GI50 values for all the cell lines tested (0.25 to 0.33 µM). This compound was encapsulated in different nanosized liposome formulations, containing egg lecithin (Egg-PC), dipalmitoyl phosphatidylcholine (DPPC), dipalmitoyl phosphatidylglycerol (DPPG), DSPC, cholesterol, dihexadecyl phosphate, and DSPE-PEG. Dynamic light scattering measurements showed that nanoliposomes with the encapsulated compound are generally monodisperse and with hydrodynamic diameters lower than 120 nm, good stability and zeta potential values lower than −18 mV. Dialysis experiments allowed to monitor compound diffusion through the lipid membrane, from DPPC/DPPG donor liposomes to NBD-labelled lipid/DPPC/DPPG acceptor liposomes. | por |
dc.description.sponsorship | Thanks are due to the Foundation for Science and Technology (FCT, Portugal) for financial support through the research centers (CFUM and CQ-UM) and project PTDC/QUI/81238/2006 (cofinanced by FEDER/COMPETE, ref. FCOMP-01-0124-FEDER-007467). A.S. Abreu (SFRH/BPD/24548/2005) and L. Vale-Silva (SFRH/BPD/29112/2006) acknowledge FCT for their postdoctoral grants. | por |
dc.language.iso | eng | por |
dc.publisher | SpringerOpen | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/81238/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F24548%2F2005/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F29112%2F2006/PT | - |
dc.rights | openAccess | por |
dc.subject | Nanoliposomes | por |
dc.subject | Antitumoral drugs | por |
dc.subject | Fluorescence | por |
dc.subject | Dialysis | por |
dc.title | Nanoliposomes for encapsulation and delivery of the potential antitumoral methyl 6-methoxy-3-(4-methoxyphenyl)-1H-indole-2-carboxylate | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.nanoscalereslett.com | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 482 | por |
oaire.citationEndPage | -- | por |
oaire.citationTitle | Nanoscale Research Letters | por |
oaire.citationVolume | 6 | por |
dc.identifier.doi | 10.1186/1556-276X-6-482 | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Nanoscale Research Letters | por |
Aparece nas coleções: | CDF - FAMO - Artigos/Papers (with refereeing) CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Nanoscale2011_Nanoliposomes.pdf | Documento principal | 336,33 kB | Adobe PDF | Ver/Abrir |