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https://hdl.handle.net/1822/9916
Título: | Fluorescence studies on potential antitumoral heteroaryl and heteroannulated indoles in solution and in lipid membranes |
Autor(es): | Castanheira, Elisabete M. S. Abreu, Ana S. Carvalho, M. Solange D. Queiroz, Maria João R. P. Ferreira, Paula M. T. |
Palavras-chave: | Heteroaryl and heteroannulated indoles Lipid membranes Fluorescence anisotropy |
Data: | Mai-2009 |
Editora: | Springer |
Revista: | Journal of Fluorescence |
Citação: | "Journal of Fluorescence." ISSN 1053-0509. 19:3 (Maio 2009) 501-509. |
Resumo(s): | Fluorescence properties of three potential antitumoral compounds, a 3-(dibenzothien-4-yl)indole 1, a phenylbenzothienoindole 2 and a 3-(dibenzofur-4-yl)indole 3, were studied in solution and in lipid aggregates of dipalmitoyl phosphatidylcholine (DPPC), dioleoyl phosphatidylethanolamine (DOPE) and egg yolk phosphatidylcholine (Egg-PC). The 3-(dibenzofur-4-yl)indole 3 exhibits the higher fluorescence quantum yields in all solvents studied (0.32 ≤ ΦF ≤ 0.51). All the compounds present a solvent sensitive emission, with significant red shifts in alcohols. The results point to an ICT character of the excited state, more pronounced for compound 1. Fluorescence (steady-state) anisotropy measurements of the compounds incorporated in lipid aggregates of DPPC, DOPE and Egg-PC indicate that the three compounds are deeply located in the lipid bilayer, feeling the difference between the rigid gel phase and fluid phases. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/9916 |
DOI: | 10.1007/s10895-008-0439-6 |
ISSN: | 1053-0509 1573-4994 |
Versão da editora: | www.springerlink.com |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDF - FAMO - Artigos/Papers (with refereeing) CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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JOFL Heteroindoles_2009.pdf | Documento principal | 414,78 kB | Adobe PDF | Ver/Abrir |