Advances in 3D neural, vascular and neurovascular models for drug testing and regenerative medicine

doi:10.1016/j.drudis.2020.11.009

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/91871

Título:	Advances in 3D neural, vascular and neurovascular models for drug testing and regenerative medicine
Autor(es):	Fernandes, Diogo C. Reis, R. L. Oliveira, Joaquim M.
Palavras-chave:	3D neural models Drug screening Regenerative medicine
Data:	Mar-2021
Editora:	Elsevier
Revista:	Drug Discovery Today
Citação:	Fernandes D. C., Reis R. L., Oliveira J. M. Advances in 3D neural, vascular and neurovascular models for drug testing and regenerative medicine, Drug Discovery Today, Vol. 26, Issue 3, pp. 754-768, doi:10.1016/j.drudis.2020.11.009, 2021
Resumo(s):	Clinical trials continue to fall short regarding drugs to effectively treat brain-affecting diseases. Althoughthere are many causes of these shortcomings, the most relevant are the inability of most therapeuticagents to cross the bloodâ brain barrier (BBB) and the failure to translate effects from animal models topatients. In this review, we analyze the most recent developments in BBB, neural, and neurovascularmodels, analyzing their impact on the drug development process by considering their quantitative andphenotypical characterization. We offer a perspective of the state-of-the-art of the models that couldrevolutionize the pharmaceutical industry.
Tipo:	Artigo
URI:	https://hdl.handle.net/1822/91871
DOI:	10.1016/j.drudis.2020.11.009
ISSN:	1741-8364
Versão da editora:	https://www.sciencedirect.com/science/article/pii/S1359644620304748
Arbitragem científica:	yes
Acesso:	Acesso restrito UMinho
Aparece nas coleções:	3B’s - Artigos em revistas/Papers in scientific journals