Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/91827
Título: | Microphysiological systems to study colorectal cancer: State-of-the-art |
Autor(es): | Ramos, Pedro Carvalho, Mariana Rodrigues Chen, Wei Yan, Le-Ping Zhang, Chang-Hua He, Yu-Long Reis, R. L. Oliveira, Joaquim M. |
Palavras-chave: | Colorectal cancer In vitro models Microphysiological systems Spheroids Patient-derived organoids Tumour microenvironment Microbiome Microfluidics |
Data: | Mar-2023 |
Editora: | IOP Publishing |
Revista: | Biofabrication |
Citação: | Ramos P., Carvalho M. R., Chen W., Yan L., Zhang C.-H., He Yu-Long, Reis R. L., Oliveira J. M. Microphysiological systems to study colorectal cancer: State-of-the-art, Biofabrication, doi:10.1088/1758-5090/acc279, 2023 |
Resumo(s): | Colorectal cancer (CRC) still has a high prevalence of mortality in the world. So far, basic pre-clinical research based on 2D cultures has failed to improve patient prognostic outcomes. A growing field of research based on microphysiological systems (MPS) involving organoids/spheroids or patient-derived tumour cells has become a solid base for a better understanding of the tumour microenvironment and as a result a step towards personalized medicine. Furthermore, microfluidic approaches have also started to open possibilities of research, with tumour-on-chips and body-on-chips being used in order to decipher complex inter-organ signalling and the prevalence of metastasis, as well as CRC early-diagnosis through liquid biopsies. Herein, we focus on the state-of-the-art of CRC research with emphasis on 3D microfluidic in vitro cultures - organoids, spheroids â drug resistance, circulating tumour cells (CTCs) and microbiome-on-a-chip technology. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/91827 |
DOI: | 10.1088/1758-5090/acc279 |
ISSN: | 1758-5090 |
Versão da editora: | https://iopscience.iop.org/article/10.1088/1758-5090/acc279 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20910-ramos-et-al-2023-biofabrication-101088-1758-5090-acc279.pdf | 1,41 MB | Adobe PDF | Ver/Abrir |