Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/91401
Título: | The role of prevotella species in female genital tract infections |
Autor(es): | George, Sheridan D. Van Gerwen, Olivia T. Dong, Chaoling Sousa, Lúcia Filipa Guimarães Vieira Cerca, Nuno Elnaggar, Jacob H. Taylor, Christopher M. Muzny, Christina A. |
Palavras-chave: | Prevotella Bacterial vaginosis Endometritis Pelvic inflammatory disease Chorioamnionitis Female genital tract infection |
Data: | 2024 |
Editora: | MDPI |
Revista: | Pathogens |
Citação: | George, Sheridan D.; Van Gerwen, Olivia T.; Dong, Chaoling; Sousa, Lúcia; Cerca, Nuno; Elnaggar, Jacob H.; Taylor, Christopher M.; Muzny, Christina A., The role of prevotella species in female genital tract infections. Pathogens, 13(5), 364, 2024 |
Resumo(s): | Female genital tract infections (FGTIs) include vaginal infections (e.g., bacterial vaginosis [BV]), endometritis, pelvic inflammatory disease [PID], and chorioamnionitis [amniotic fluid infection]. They commonly occur in women of reproductive age and are strongly associated with multiple adverse health outcomes including increased risk of HIV/sexually transmitted infection acquisition and transmission, infertility, and adverse birth outcomes such as preterm birth. These FGTIs are characterized by a disruption of the cervicovaginal microbiota which largely affects host immunity through the loss of protective, lactic acid-producing Lactobacillus spp. and the overgrowth of facultative and strict anaerobic bacteria. Prevotella species (spp.), anaerobic Gram-negative rods, are implicated in the pathogenesis of multiple bacterial FGTIs. Specifically, P. bivia, P. amnii, and P. timonensis have unique virulence factors in this setting, including resistance to antibiotics commonly used in treatment. Additionally, evidence suggests that the presence of Prevotella spp. in untreated BV cases can lead to infections of the upper female genital tract by ascension into the uterus. This narrative review aims to explore the most common Prevotella spp. in FGTIs, highlight their important role in the pathogenesis of FGTIs, and propose future research in this area. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/91401 |
DOI: | 10.3390/pathogens13050364 |
ISSN: | 2076-0817 |
Versão da editora: | http://www.mdpi.com/journal/pathogens |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_57725_1.pdf | 1,15 MB | Adobe PDF | Ver/Abrir |