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https://hdl.handle.net/1822/91180
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Campo DC | Valor | Idioma |
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dc.contributor.author | Matamá, Maria Teresa Gonçalves Macedo | por |
dc.contributor.author | Costa, Cristiana Filipa Chaves | por |
dc.contributor.author | Fernandes, Bruno | por |
dc.contributor.author | Araújo, Rita | por |
dc.contributor.author | Cruz, Célia F. | por |
dc.contributor.author | Tortosa, Francisco | por |
dc.contributor.author | Singh, Caroline Jeya Sheeba Daniel Sunder | por |
dc.contributor.author | Becker, Jörg D. | por |
dc.contributor.author | Gomes, Andreia C | por |
dc.contributor.author | Cavaco-Paulo, Artur | por |
dc.date.accessioned | 2024-04-22T12:24:39Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 2090-1232 | - |
dc.identifier.uri | https://hdl.handle.net/1822/91180 | - |
dc.description.abstract | Introduction: Natural hair curvature and colour are genetically determined human traits, that we inten tionally change by applying thermal and chemical treatments to the fibre. Presently, those cosmetic methodologies act externally and their recurrent use is quite detrimental to hair fibre quality and even to our health. Objectives: This work represents a disruptive concept to modify natural hair colour and curvature. We aim to model the fibre phenotype as it is actively produced in the follicle through the topical delivery of specific bioactive molecules to the scalp. Methods: Transcriptome differences between curly and straight hairs were identified by microarray. In scalp samples, the most variable transcripts were mapped by in situ hybridization. Then, by using appro priate cellular models, we screened a chemical library of 1200 generic drugs, searching for molecules that could lead to changes in either fibre colour or curvature. A pilot-scale, single-centre, investigator initiated, prospective, blind, bilateral (split-scalp) placebo-controlled clinical study with the intervention of cosmetics was conducted to obtain a proof of concept (RNEC n.92938). Results: We found 85 genes transcribed significantly different between curly and straight hair, not pre viously associated with this human trait. Next, we mapped some of the most variable genes to the inner root sheath of follicles, reinforcing the role of this cell layer in fibre shape moulding. From the drug library screening, we selected 3 and 4 hits as modulators of melanin synthesis and gene transcription, respec tively, to be further tested in 33 volunteers. The intentional specific hair change occurred: 8 of 14 volun teers exhibited colour changes, and 16 of 19 volunteers presented curvature modifications, by the end of the study. Conclusion: The promising results obtained are the first step towards future cosmetics, complementary or alternative to current methodologies, taking hair styling to a new level: changing hair from the inside out. | por |
dc.description.sponsorship | This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2020 unit, and by LABBELS – Associate Laboratory in Biotechnology, Bioengineering and Microelectrome chanical Systems, LA/P/0029/2020. Teresa Matamá would like to acknowledge her Post-doctoral scholarship funded by FCT (SFRH/ BPD/102153/2014). Cristiana Costa would like to acknowledge her PhD scholarship funded by FCT (SFRH/BD/139522/2018). Bruno Fernandes would like to acknowledge his PhD scholarship funded by FCT (SFRH/BD/131824/2017). | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04469%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F102153%2F2014/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F139522%2F2018/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F131824%2F2017/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Melanocytes | por |
dc.subject | Melanogenesis | por |
dc.subject | Corneocytes | por |
dc.subject | Terminal differentiation | por |
dc.subject | Cosmeceuticals | por |
dc.subject | Drug repurposing | por |
dc.title | Changing human hair fibre colour and shape from the follicle | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2090123223003508 | por |
dc.identifier.eissn | 2090-1224 | - |
dc.identifier.doi | 10.1016/j.jare.2023.11.013 | por |
dc.date.embargo | 10000-01-01 | - |
dc.subject.fos | Engenharia e Tecnologia::Outras Engenharias e Tecnologias | por |
sdum.journal | Journal of Advanced Research | por |
oaire.version | VoR | por |
dc.subject.ods | Saúde de qualidade | por |
Aparece nas coleções: | CBMA - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1-s2.0-S2090123223003508-main.pdf Acesso restrito! | 2,98 MB | Adobe PDF | Ver/Abrir |