Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/91156
Título: | Neuromodulation of acid-sensitive ion channels (ASICs) and anti-inflammatory potential by lichenxanthone in adult zebrafish(Danio rerio):Experimental and docking studies |
Autor(es): | Liberato,Hortência Ribeiro Maciel, Jéssica Bezerra Silva, Antônio Wlisses Da Bezerra, Maria Eduarda Uchoa Brito, Luana San De Oliveira Silva, Jacilene Ferreira, Maria Kuerislene Amâncio Marinho, Marcia Machado Marinho, Gabrielle S. Pessoa, Otília Deusdênia Loiola Guedes, Maria Izabel F. Silva, Paulo Goberlânio De Barros Gomes, Andreia C Menezes, Jane Eire Silva Alencar De Santos, Hélcio Silva dos |
Palavras-chave: | Acute toxicity Anti-inflammatory Erythroxylum bezerrae Locomotor behavior Molecular docking Neuromodulation of ASICs Xanthone |
Data: | 2024 |
Editora: | Wiley-VHCA |
Revista: | Chemistry and Biodiversity |
Resumo(s): | The xanthone lichenxanthone did not show toxic effects (LC50>1.0 mg/mL). lichenxanthone prevented nociceptive behavior induced by acidic saline, and its analgesic effect was blocked by amiloride, highlighting the involvement of neuromodulation of acid-sensitive ion channels (ASICs). In the analysis of anti-inflammatory activity, concentrations of 0.1 and 0.5 mg/mL of lichenxanthone reduced the edema induced by k-carrageenan 3.5 %, observed from the fourth hour of analysis. This effect was similar to that observed with ibuprofen (positive control). No leukocyte infiltrates were observed in lichenxanthone, suggesting that the compound acts in the acute inflammatory response. The results of the molecular docking study revealed that lichenxanthone exhibited better affinity energy when compared to the ibuprofen control against the two targets evaluated. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/91156 |
DOI: | 10.1002/cbdv.202400063 |
Versão da editora: | https://onlinelibrary.wiley.com/doi/full/10.1002/cbdv.202400063 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CBMA - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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202400063 Hortencia.pdf Acesso restrito! | 1,71 MB | Adobe PDF | Ver/Abrir |