Investigating the photophysical properties and biological  efficacy of BODIPY derivatives as photosensitizers in  photodynamic therapy

doi:10.3390/ecsoc-27-16094

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/90083

Título:	Investigating the photophysical properties and biological efficacy of BODIPY derivatives as photosensitizers in photodynamic therapy
Autor(es):	Gonçalves, Raquel Costa Raínha Pinto, Sónia Catarina Silva Pina, João Gomes-da-Silva, Lígia C. Costa, Susana P. G. Raposo, M. Manuela M.
Palavras-chave:	BODIPY derivative Cancer therapy Photosensitizers PDT Singlet oxygen quantum yield Synthesis Heterocycles Vilsmeier formylation In vitro assays Photodynamic therapy
Data:	2023
Editora:	MDPI
Citação:	Gonçalves, R. C. R.; Pinto, S. C. S.; Pina, J.; Gomes-da-Silva, L. C.; Costa, S. P. G.; Raposo, M. M. M. Investigating the photophysical properties and biological efficacy of BODIPY derivatives as photosensitizers in photodynamic therapy. Proceedings of the 27th International Electronic Conference on Synthetic Organic Chemistry. Chem. Proc. 2023, 14(1), 71. https://doi.org/10.3390/ecsoc-27-16094
Resumo(s):	The selectivity of photosensitizers for light activation is a key advantage in photodynamic therapy (PDT), allowing for precise targeting while sparing healthy cells. BODIPY derivatives have emerged as promising PDT candidates due to their tunable photophysical properties and versatile synthesis. Herein, we explore the photophysical characterization and the in vitro photodynamic activity of BODIPY analogues meso-substituted with an anthracene moiety and functionalized with iodine atoms or formyl group at 2,6-position. The formylated anthracene-BODIPY derivative exhibited the highest tumor suppression under irradiation, making it a potential candidate as PDT photosensitizer.
Tipo:	Artigo em ata de conferência
URI:	https://hdl.handle.net/1822/90083
DOI:	10.3390/ecsoc-27-16094
Versão da editora:	https://doi.org/10.3390/ecsoc-27-16094
Arbitragem científica:	yes
Acesso:	Acesso aberto
Aparece nas coleções:	CDQuim - Comunicações e Proceedings