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https://hdl.handle.net/1822/90083
Título: | Investigating the photophysical properties and biological efficacy of BODIPY derivatives as photosensitizers in photodynamic therapy |
Autor(es): | Gonçalves, Raquel Costa Raínha Pinto, Sónia Catarina Silva Pina, João Gomes-da-Silva, Lígia C. Costa, Susana P. G. Raposo, M. Manuela M. |
Palavras-chave: | BODIPY derivative Cancer therapy Photosensitizers PDT Singlet oxygen quantum yield Synthesis Heterocycles Vilsmeier formylation In vitro assays Photodynamic therapy |
Data: | 2023 |
Editora: | MDPI |
Citação: | Gonçalves, R. C. R.; Pinto, S. C. S.; Pina, J.; Gomes-da-Silva, L. C.; Costa, S. P. G.; Raposo, M. M. M. Investigating the photophysical properties and biological efficacy of BODIPY derivatives as photosensitizers in photodynamic therapy. Proceedings of the 27th International Electronic Conference on Synthetic Organic Chemistry. Chem. Proc. 2023, 14(1), 71. https://doi.org/10.3390/ecsoc-27-16094 |
Resumo(s): | The selectivity of photosensitizers for light activation is a key advantage in photodynamic therapy (PDT), allowing for precise targeting while sparing healthy cells. BODIPY derivatives have emerged as promising PDT candidates due to their tunable photophysical properties and versatile synthesis. Herein, we explore the photophysical characterization and the in vitro photodynamic activity of BODIPY analogues meso-substituted with an anthracene moiety and functionalized with iodine atoms or formyl group at 2,6-position. The formylated anthracene-BODIPY derivative exhibited the highest tumor suppression under irradiation, making it a potential candidate as PDT photosensitizer. |
Tipo: | Artigo em ata de conferência |
URI: | https://hdl.handle.net/1822/90083 |
DOI: | 10.3390/ecsoc-27-16094 |
Versão da editora: | https://doi.org/10.3390/ecsoc-27-16094 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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chemproc-14-00071.pdf | proceeding | 3,08 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons