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https://hdl.handle.net/1822/90078
Título: | Osseointegration assessment of multi-material Ti6Al4V-βTCP implants: an experimental study in rats |
Autor(es): | Costa, Ana Mafalda Meneses Miranda, Alice Augusta Macedo Bartolomeu, Flávio Carvalho, Óscar Samuel Novais Matos, Sergio Silva, Filipe Samuel Miranda, Maria Georgina Macedo |
Palavras-chave: | In vivo Laser surface texturing Multi-material Osseointegration Ti6Al4V-beta TCP Ti6Al4V-β TCP |
Data: | Jun-2022 |
Editora: | Wiley |
Revista: | Advanced Materials Technologies |
Citação: | M. M. Costa, A. Miranda, F. Bartolomeu, Ó. Carvalho, S. Matos, F. S. Silva, G. Miranda, Osseointegration Assessment of Multi-Material Ti6Al4V-β TCP Implants: An Experimental Study in Rats. Adv. Mater. Technol. 2022, 7, 2101117. https://doi.org/10.1002/admt.202101117 |
Resumo(s): | In the present study, mono- and multi-material laser textured Ti6Al4V implants are manufactured and characterized in vivo to explore their applicability in orthopedic implants. Laser surface texturing is used for manufacturing grooved Ti6Al4V implants while a pressure-assisted sintering technique is employed to impregnate beta-tricalcium phosphate into grooves for an improved bioactivity. After implantation into Sprague Dawley rat's femur for 4 and 12 weeks, bone-implant fixation and osseointegration are assessed, by performing push-out tests and histological characterization. Histological characterization showed bone formation around all implants, characterized by immature bone at 4 weeks of implantation and a more mature bone after 12 weeks. The maximum push-out forces are higher for the textured and multi-material solution, when compared to non-textured implants right after 4 weeks of implantation (p < 0.05). After 12 weeks, multi-material implant displayed higher fracture energy when compared to non-textured implants (p < 0.05). Results revealed that laser surface texturing and bioactive multi-material solutions are highly effective to promote bone regeneration and enhance bone-implant fixation for further application in orthopedic implants. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/90078 |
DOI: | 10.1002/admt.202101117 |
ISSN: | 2365-709X |
Versão da editora: | https://onlinelibrary.wiley.com/doi/full/10.1002/admt.202101117 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals CMEMS - Artigos em revistas internacionais/Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Osseointegration Assessment of Multi-Material Ti6Al4V- TCP Implants An.pdf Acesso restrito! | 1,14 MB | Adobe PDF | Ver/Abrir |