Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/90028
Título: | Mechanomodulatory biomaterials prospects in scar prevention and treatment |
Autor(es): | Fernandes, Maria Goreti Antunes da Silva, Lucília Pereira Cerqueira, Mariana Teixeira Ibanez, Rita Murphy, Ciara M. Reis, R. L. OBrien, Fergal J. Marques, A. P. |
Palavras-chave: | Mechanics Mechanobiological signalling Mechanomodulatory biomaterials Scar Wound healing |
Data: | Jul-2022 |
Editora: | Elsevier 1 |
Revista: | Acta Biomaterialia |
Citação: | Fernandes M. F., da Silva L. P., Cerqueira M. T., Ibanez R., Murphy C. M., Reis R. L., OBrien F. J., Marques A. P. Mechanomodulatory biomaterials prospects in scar prevention and treatment, Acta Biomaterialia, Vol. 150, pp. 22-23, doi:10.1016/j.actbio.2022.07.042, 2022 |
Resumo(s): | Scarring is a major clinical issue that affects a considerable number of patients. The associated problems go beyond the loss of skin functionality, as scars bring aesthetic, psychological, and social difficulties. Therefore, new strategies are required to improve the process of healing and minimize scar formation. Research has highlighted the important role of mechanical forces in the process of skin tissue repair and scar formation, in addition to the chemical signalling. A more complete understanding of how engi- neered biomaterials can modulate these mechanical stimuli and modify the mechanotransduction signals in the wound microenvironment is expected to enable scar tissue reduction. The present review aims to provide an overview of our current understanding of skin biomechanics and mechanobiology underlying wound healing and scar formation, with an emphasis on the development of novel mechanomodulatory wound dressings with the capacity to offload mechanical tension in the wound environment. Further- more, a broad overview of current challenges and future perspectives of promising mechanomodulatory biomaterials for this application are provided. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/90028 |
DOI: | 10.1016/j.actbio.2022.07.042 |
ISSN: | 1742-7061 |
e-ISSN: | 1878-7568 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S1742706122004445?via%3Dihub |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21125-32-2022-mf.pdf | 1,63 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons