Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/90019
Título: | A multifunctional photoacoustic/fluorescence dual-mode-imaging gold-based theranostic nanoformulation without external laser limitations |
Autor(es): | Zhang, Junfeng Yin, Xiaofeng Li, Chenchen Yin, Xuelian Xue, Qianghua Ding, Lin Ju, Jiale Ma, Jifei Zhu, Ying Du, Dongshu Reis, R. L. Wang, Yanli |
Palavras-chave: | Gold nanorods Mitochondria-mediated apoptosis Photoacoustic and fluorescence imaging Reactive oxygen species Theranostic nanoformulation |
Data: | Mar-2022 |
Editora: | Wiley |
Revista: | Advanced Materials |
Citação: | Zhang J. F., Yin X. F., Li C. C., Yin X. L., Xue Q. H., Ding L., Ju J. L., Ma J. F., Zhu Y., Du D. S., Reis R. L., Wang Y. L. A Multifunctional Photoacoustic/Fluorescence Dual-Mode-Imaging Gold-Based Theranostic Nanoformulation without External Laser Limitations, Advanced Materials, Vol. 34, Issue 19, pp. 2110690, doi:https://doi.org/10.1002/adma.202110690ope, 2022 |
Resumo(s): | Theranostics is a new type of biomedical technology that organically combines the diagnosis and therapy of diseases. Among molecular imaging techniques, the integration of photoacoustic (PA) and fluorescence (FL) imaging modes with high sensitivity and imaging depth provides precise diagnostic outcomes. Gold nanorods (Au NRs) are well-known contrast agents for PA imaging and photothermal therapy. However, their high toxicity, poor biocompatibility, rapid clearance, and the need for an external laser source limit their application. Therefore, modification of Au NRs with carbon-based nanomaterials (CBNs) is done to obtain a multifunctional dual-mode gold-based nanoformulation (mdGC), which preforms dual-mode imaging of PA and FL. The results show that mdGC promotes tumor cell apoptosis and exhibits good antitumor performance through the mitochondria-mediated apoptotic pathway by increasing the production of intracellular reactive oxygen species, reducing mitochondrial membrane potential, and regulating the expression of apoptosis-related genes. The targeting rate of mdGC to tumor tissue is up to 20.71 ± 1.94% ID g-1; the tumor growth inhibition rate is as high as 80.44% without external laser sources. In general, mdGC is a potential multifunctional diagnostic and therapy integrated nanoformulation. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/90019 |
DOI: | 10.1002/adma.202110690ope |
ISSN: | 0935-9648 |
e-ISSN: | 1521-4095 |
Versão da editora: | https://onlinelibrary.wiley.com/doi/10.1002/adma.202110690 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21123-advanced-materials-2022-zhang-multifunctional-photoacoustic-fluorescence-dual‐mode‐imaging-gold‐base.pdf | 4,15 MB | Adobe PDF | Ver/Abrir |