Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/90015
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Campo DC | Valor | Idioma |
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dc.contributor.author | Chen, Xuerui | por |
dc.contributor.author | Yin, Xuelian | por |
dc.contributor.author | Zhan, Lin | por |
dc.contributor.author | Zhang, Junfeng | por |
dc.contributor.author | Zhang, Yuxi | por |
dc.contributor.author | Wu, Yinghua | por |
dc.contributor.author | Ju, Jiale | por |
dc.contributor.author | Li, Yajie | por |
dc.contributor.author | Xue, Qianghua | por |
dc.contributor.author | Wang, Xu | por |
dc.contributor.author | Li, Chenchen | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Wang, Yanli | por |
dc.date.accessioned | 2024-03-26T09:17:39Z | - |
dc.date.available | 2024-03-26T09:17:39Z | - |
dc.date.issued | 2021-12 | - |
dc.date.submitted | 2024-03 | - |
dc.identifier.citation | Chen X. R., Yin X. L., Zhan L., Zhang J. F., Zhang Y. X., Wu Y. H., Ju J. L., Li Y. J., Xue Q. H., Wang X., Li C. C., Reis R. L., Wang Y. L. Organelle-Specific Anchored Delivery System Stretching a Reversal of Tumor Hypoxia Microenvironment to a Combinational Chemo-Photothermal Therapy, Advanced Functional Materials, Vol. 32, Issue 15, pp. 1-10, doi:https://doi.org/10.1002/adfm.202108603, 2021 | por |
dc.identifier.issn | 1616-301X | por |
dc.identifier.uri | https://hdl.handle.net/1822/90015 | - |
dc.description.abstract | Direct delivery to an organelle-specific point can boost the efficacy of therapy procedures to new heights. Among other subcellular organelles, mitochondria generate ATP as intracellular powerhouse, and are associated with multiple aspects of tumorigenesis and tumor development. Here, a mitochondrial anchored biomimetic nanoplatform (CZACN) is designed and its reversal of tumor hypoxia microenvironment underlying the mitochondria-located chemo-photothermal therapy is studied. After shuttling into cancer cells, therapeutic payloads including cisplatin (CDDP) and Au nanozymes are controllably released in the ATP-overexpressed mitochondria. CDDP generates O2â ¢â , forms H2O2 for a chemical fuel in the next reaction, and damages mitochondrial DNA. Meanwhile, the catalase-like Au nanozymes catalyze the produced hydrogen peroxide for oxygen supply to relieve hypoxic tumor microenvironment, offering cytotoxic singlet oxygen against cancer cells under NIR treatment. As a result of cancer-cell self-recognition, mitochondria-targeted therapy, and photothermal conversion ability, the fabricated CZACNs obtained 89.2 ± 3.70% of tumor growth inhibition under NIR irradiation and constrained the dose-limiting toxicity of CDDP, as well. These findings reinforce the synergistic effect of organelle-specific navigation and in situ oxygen self-sufficiency for combinational chemo-photothermal therapy. | por |
dc.description.sponsorship | X.C., X.Y., and L.Z. contributed equally to this work. This work has been supported by the National Natural Science Foundation of China (22003038, 81922037, and 11575107), the Shanghai University-Universal Medical Imaging Diagnostic Research Foundation (19H00100), Shanghai Biomedical Science and Technology Support Project (19441903600), the Program for Changjiang Scholars and Innovative Research Team in University (IRT13078). The authors would like to thank the workers from Shiyanjia Lab (www.shiyanjia.com) for the ICP-OES analysis. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley | por |
dc.rights | openAccess | por |
dc.subject | Cancer | por |
dc.subject | Chemo-photothermal therapy | por |
dc.subject | Delivery system | por |
dc.subject | Organelle | por |
dc.subject | Biomimetic membrane coating | por |
dc.subject | Metal organic frameworks | por |
dc.subject | Organelle-specific | por |
dc.subject | Tumor hypoxia microenvironment | por |
dc.title | Organelle-specific anchored delivery system stretching a reversal of tumor hypoxia microenvironment to a combinational chemo-photothermal therapy | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/adfm.202108603 | por |
dc.comments | http://3bs.uminho.pt/node/21108 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 10 | por |
oaire.citationIssue | 15 | por |
oaire.citationVolume | 32 | por |
dc.date.updated | 2024-03-21T09:25:05Z | - |
dc.identifier.eissn | 1616-3028 | por |
dc.identifier.doi | 10.1002/adfm.202108603 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Advanced Functional Materials | por |
oaire.version | VoR | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21108-adv-funct-materials-2021-chen-organelle‐specific-anchored-delivery-system-stretching-reversal-tumor-.pdf | 3,63 MB | Adobe PDF | Ver/Abrir |