Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/89992
Título: | Drug delivery systems for photodynamic therapy: the potentiality and versatility of electrospun nanofibers |
Autor(es): | Costa, Sofia M. Fangueiro, Raúl Ferreira, Diana P. |
Palavras-chave: | Drug delivery systems Drug liberation Pharmaceutical preparations Polymers Nanofibers Photochemotherapy biodegradable polymers cancer electrospun nanofibers infections photodynamic therapy |
Data: | Mai-2022 |
Editora: | Wiley |
Revista: | Macromolecular Bioscience |
Resumo(s): | Recently, photodynamic therapy (PDT) has become a promising approach for the treatment of a broad range of diseases, including oncological and infectious diseases. This minimally invasive and localized therapy is based on the production of reactive oxygen species able to destroy cancer cells and inactivate pathogens by combining the use of photosensitizers (PSs), light, and molecular oxygen. To overcome the drawbacks of drug systemic administration, drug delivery systems (DDS) can be used to carrier the PSs, allowing higher therapeutic efficacy and minimal toxicological effects. Polymeric nanofibers produced by electrospinning emerged as powerful platforms for drug delivery applications. Electrospun nanofibers exhibit outstanding characteristics, such as large surface-area-to-volume ratio associated with high drug loading, high porosity, flexibility, ability to incorporate and release a wide variety of therapeutic agents, biocompatibility, and biodegradability. Due to the versatility of this technique, fibers with different morphologies and functionalities, including drug release profile can be produced. The possibility of scalability makes electrospinning even more attractive for the development of DDS. This review aims to explore and show an up to date of the huge potential of electrospun nanofibers as DDS for different PDT applications and discuss the opportunities and challenges in this field. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/89992 |
DOI: | 10.1002/mabi.202100512 |
ISSN: | 1616-5187 |
e-ISSN: | 1616-5195 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | DET/2C2T - Artigos em revistas internacionais com arbitragem científica |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Macromolecular Bioscience - 2022 - Costa - Drug Delivery Systems for Photodynamic Therapy The Potentiality and Versatility.pdf | 3,28 MB | Adobe PDF | Ver/Abrir |