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https://hdl.handle.net/1822/88814
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Campo DC | Valor | Idioma |
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dc.contributor.author | Wu, Jiaxue | por |
dc.contributor.author | Yi, Shixiong | por |
dc.contributor.author | Cao, Yingui | por |
dc.contributor.author | Zu, Menghang | por |
dc.contributor.author | Li, Baoyi | por |
dc.contributor.author | Yang, Wenjing | por |
dc.contributor.author | Shahbazi, Mohammad-Ali | por |
dc.contributor.author | Wan, Ying | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Kundu, Subhas C | por |
dc.contributor.author | Shi, Xiaoxiao | por |
dc.contributor.author | Xiao, Bo | por |
dc.date.accessioned | 2024-02-19T09:53:29Z | - |
dc.date.available | 2024-02-19T09:53:29Z | - |
dc.date.issued | 2023-11 | - |
dc.date.submitted | 2024-02 | - |
dc.identifier.citation | Wu J., Yi S., Cao Y., Zu M., Li B., Yang W., Shahbazi M. - A., Wang Y., Reis R. L., Kundu S. C., Shi X., Xiao B. Dual-driven nanomotors enable tumour penetration and hypoxia alleviation for calcium overload-photo-immunotherapy against colorectal cancer, Biomaterials, Vol. 302, pp. 122332, doi:10.1016/j.biomaterials.2023.122332, 2023 | por |
dc.identifier.issn | 0142-9612 | por |
dc.identifier.uri | https://hdl.handle.net/1822/88814 | - |
dc.description.abstract | The treatment efficacies of conventional medications against colorectal cancer (CRC) are restricted by a low penetrative, hypoxic, and immunosuppressive tumor microenvironment. To address these restrictions, we developed an innovative antitumor platform that employs calcium overload-phototherapy using mitochondrial N770-conjugated mesoporous silica nanoparticles loaded with CaO2 (CaO2–N770@MSNs). A loading level of 14.0 wt% for CaO2–N770@MSNs was measured, constituting an adequate therapeutic dosage. With the combination of oxygen generated from CaO2 and hyperthermia under near-infrared irradiation, CaO2–N770@MSNs penetrated through the dense mucus, accumulated in the colorectal tumor tissues, and inhibited tumor cell growth through endoplasmic reticulum stress and mitochondrial damage. The combination of calcium overload and phototherapy revealed high therapeutic efficacy against orthotopic colorectal tumors, alleviated the immunosuppressive microenvironment, elevated the abundance of beneficial microorganisms (e.g., Lactobacillaceae and Lachnospiraceae), and decreased harmful microorganisms (e.g., Bacteroidaceae and Muribaculaceae). Moreover, together with immune checkpoint blocker (αPD-L1), these nanoparticles showed an ability to eradicate both orthotopic and distant tumors, while potentiating systemic antitumor immunity. This treatment platform (CaO2–N770@MSNs plus αPD-L1) open a new horizon of synergistic treatment against hypoxic CRC with high killing power and safety. | eng |
dc.description.sponsorship | This study was supported by the National Natural Science Foundation of China (82072060 and 22008201), the Fundamental Research Funds for the Central Universities (SWU-XDPY22006 and SWUKQ22075), the Venture & Innovation Support Program for Chongqing Overseas Returnees (2205012980212766), the Distinguished Young Scholars of Chongqing (2022NSCQ-JQX5279), and the Natural Science Foundation Project of Chongqing (cstc2020jcyj-msxmX0292). | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | restrictedAccess | por |
dc.subject | Calcium overload | por |
dc.subject | Hypoxic alleviation | por |
dc.subject | Immunogenic cell death | por |
dc.subject | Intestinal microbiota | por |
dc.subject | Nanomotor | por |
dc.subject | Phototherapy | por |
dc.title | Dual-driven nanomotors enable tumour penetration and hypoxia alleviation for calcium overload-photo-immunotherapy against colorectal cancer | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S014296122300340X | por |
dc.comments | http://3bs.uminho.pt/node/21057 | por |
oaire.citationVolume | 302 | por |
dc.date.updated | 2024-02-07T16:43:11Z | - |
dc.identifier.eissn | 1878-5905 | por |
dc.identifier.doi | 10.1016/j.biomaterials.2023.122332 | por |
dc.identifier.pmid | 37801790 | por |
sdum.journal | Biomaterials | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21057-skundu-biomat2023.pdf Acesso restrito! | 16,21 MB | Adobe PDF | Ver/Abrir |