Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/87205
Título: | Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods |
Autor(es): | Loureiro-Campos, Eduardo Mateus-Pinheiro, António Patrício, Patrícia Cunha, Carina Isabel Soares Silva, Joana Sardinha, Vanessa Alexandra Morais Pinheiro, Bárbara Filipa Mendes Silveira-Rosa, Tiago Domingues, Ana Verónica Mendes Rodrigues, Ana João Oliveira, João Sousa, Nuno Alves, Nuno Dinis Lopes Oliveira Pinto, Luísa |
Data: | 2021 |
Editora: | eLife Sciences Publications |
Revista: | Elife |
Citação: | Loureiro-Campos, E., Mateus-Pinheiro, A., Patrício, P., Soares-Cunha, C., Silva, J., Sardinha, V. M., … Pinto, L. (2021, December 3). Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods. eLife. eLife Sciences Publications, Ltd. http://doi.org/10.7554/elife.70685 |
Resumo(s): | The transcription factor activating protein two gamma (AP2γ) is an important regulator of neurogenesis both during embryonic development as well as in the postnatal brain, but its role for neurophysiology and behavior at distinct postnatal periods is still unclear. In this work, we explored the neurogenic, behavioral, and functional impact of a constitutive and heterozygous AP2γ deletion in mice from early postnatal development until adulthood. AP2γ deficiency promotes downregulation of hippocampal glutamatergic neurogenesis, altering the ontogeny of emotional and memory behaviors associated with hippocampus formation. The impairments induced by AP2γ constitutive deletion since early development leads to an anxious-like phenotype and memory impairments as early as the juvenile phase. These behavioral impairments either persist from the juvenile phase to adulthood or emerge in adult mice with deficits in behavioral flexibility and object location recognition. Collectively, we observed a progressive and cumulative impact of constitutive AP2γ deficiency on the hippocampal glutamatergic neurogenic process, as well as alterations on limbic-cortical connectivity, together with functional behavioral impairments. The results herein presented demonstrate the modulatory role exerted by the AP2γ transcription factor and the relevance of hippocampal neurogenesis in the development of emotional states and memory processes. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/87205 |
DOI: | 10.7554/eLife.70685 |
Versão da editora: | https://elifesciences.org/articles/70685 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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elife-70685-v2.pdf | 4,55 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons