Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/87082
Título: | The yeast protein kinase Sch9 functions as a central nutrient-responsive hub that calibrates metabolic and stress-related responses |
Autor(es): | Caligaris, Marco Marques, Maria Belém Sousa Sampaio Hatakeyama, Riko Pillet, Benjamin Ludovico, Paula De Virgilio, Claudio Winderickx, Joris Nicastro, Raffaele |
Palavras-chave: | Sch9 TORC1 SNF1 Pkh1 Pkh2 Pkh3 Pho85 Lipid Stress Longevity |
Data: | 26-Jul-2023 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Journal of Fungi |
Citação: | Caligaris, M.; Sampaio-Marques, B.; Hatakeyama, R.; Pillet, B.; Ludovico, P.; De Virgilio, C.; Winderickx, J.; Nicastro, R. The Yeast Protein Kinase Sch9 Functions as a Central Nutrient-Responsive Hub That Calibrates Metabolic and Stress-Related Responses. J. Fungi 2023, 9, 787. https://doi.org/10.3390/jof9080787 |
Resumo(s): | Yeast cells are equipped with different nutrient signaling pathways that enable them to sense the availability of various nutrients and adjust metabolism and growth accordingly. These pathways are part of an intricate network since most of them are cross-regulated and subject to feedback regulation at different levels. In yeast, a central role is played by Sch9, a protein kinase that functions as a proximal effector of the conserved growth-regulatory TORC1 complex to mediate information on the availability of free amino acids. However, recent studies established that Sch9 is more than a TORC1-effector as its activity is tuned by several other kinases. This allows Sch9 to function as an integrator that aligns different input signals to achieve accuracy in metabolic responses and stress-related molecular adaptations. In this review, we highlight the latest findings on the structure and regulation of Sch9, as well as its role as a nutrient-responsive hub that impacts on growth and longevity of yeast cells. Given that most key players impinging on Sch9 are well-conserved, we also discuss how studies on Sch9 can be instrumental to further elucidate mechanisms underpinning healthy aging in mammalians. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/87082 |
DOI: | 10.3390/jof9080787 |
e-ISSN: | 2309-608X |
Versão da editora: | https://www.mdpi.com/2309-608X/9/8/787 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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jof-09-00787.pdf | 1,36 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons