Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/87029
Título: | Pullulan hydrogels as drug release platforms in biomedicine |
Autor(es): | Teixeira, Marta Sofia Aguiar Carvalho Oliveira Marinho, Elina Margarida Ribeiro Silva, C. Antunes, Joana Isabel Costa Felgueiras, Helena Prado |
Palavras-chave: | Biodegradable hydrogel Controlled release Drug delivery platforms Pullulan polymer |
Data: | 12-Out-2023 |
Editora: | Elsevier 1 |
Revista: | Journal of Drug Delivery Science and Technology |
Citação: | Teixeira, M. O., Marinho, E., Silva, C., Antunes, J. C., & Felgueiras, H. P. (2023, November). Pullulan hydrogels as drug release platforms in biomedicine. Journal of Drug Delivery Science and Technology. Elsevier BV. http://doi.org/10.1016/j.jddst.2023.105066 |
Resumo(s): | It is increasingly urgent to develop new therapeutic systems to combat the spreading and evolution of various pathologies globally. Nonspecific therapies and/or insufficient medication biodistribution might hinder the patient's recovery. In this sense, a targeted and controlled delivery of various biomolecules allows overcoming the limitations of conventional delivery systems, taking the user one step closer to the successful treatment of a disease. Hydrogels have been highlighted for their drug delivery abilities, particularly for their tunable properties, like hydration capacity, biodegradability, release kinetics, etc., that can be adjusted to the desired needs. Additionally, they can be produced from either natural and/or synthetic polymers, with natural-origin sources providing exceptional features like biodegradation and acceptable integration in biological systems. One of those polymers is pullulan, a biodegradable, biocompatible and hemocompatible material, with multiple uses in biomedicine. Investigations into pullulan-based hydrogels have progressively increased over the last few decades. This review addresses the uses of pullulan in biomedical engineering, emphasizing its exceptional properties for drug delivery and its processing into hydrogel systems, either in its original or derivative forms. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/87029 |
DOI: | 10.1016/j.jddst.2023.105066 |
ISSN: | 1773-2247 |
e-ISSN: | 2588-8943 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S1773224723009188 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series DET/2C2T - Artigos em revistas internacionais com arbitragem científica |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2023 Journal of Drug Delivery Science and Technology.pdf | 2,88 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons