Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/86437
Título: | Light-induced cleavage of model phenylalanine conjugates based on coumarins and quinolones |
Autor(es): | Fonseca, Andrea S. C. Gonçalves, M. Sameiro T. Costa, Susana P. G. |
Palavras-chave: | Coumarin Quinolone Bioconjugates Amino acids Photocleavable protecting groups |
Data: | Ago-2010 |
Editora: | Springer |
Revista: | Amino Acids |
Citação: | Fonseca, A.S.C., Gonçalves, M.S.T. & Costa, S.P.G. Light-induced cleavage of model phenylalanine conjugates based on coumarins and quinolones. Amino Acids 39, 699–712 (2010). https://doi.org/10.1007/s00726-010-0492-8 |
Resumo(s): | In order to evaluate the application of quinolone as a new photocleavable protecting group, in comparison with coumarin, a series of model phenylalanine conjugates were prepared by reaction with chloromethylated O and N heterocycles. The photophysical properties of the resulting ester conjugates were evaluated as well as the photosensitivity under irradiation at 250, 300, 350, and 419 nm. The results obtained showed that the quinolone conjugates were readily photolysed, with complete release of the amino acid in short irradiation times and could be considered a new addition to the family of photocleavable protecting groups for the carboxylic acid function of amino acids. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/86437 |
DOI: | 10.1007/s00726-010-0492-8 |
ISSN: | 0939-4451 |
Versão da editora: | https://link.springer.com/article/10.1007/s00726-010-0492-8 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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revised manuscript.pdf | Author's Accepted Manuscript | 540,42 kB | Adobe PDF | Ver/Abrir |