Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/85642
Título: | Fucoidan from Fucus vesiculosus inhibits inflammatory response, both in vitro and in vivo |
Autor(es): | Wang, Lingzhi Oliveira, Ana Catarina Freitas Salazar Li, Qiu Ferreira, Andreia S. Nunes, Cláudia Coimbra, Manuel A. Reis, R. L. Martins, Albino Wang, Chunming Silva, Tiago H. Feng, Yanxian |
Palavras-chave: | Fucoidan Fucus vesiculosus Anti-inflammatory Macrophage |
Data: | 17-Mai-2023 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Marine Drugs |
Citação: | Wang, L.; Oliveira, C.; Li, Q.; Ferreira, A.S.; Nunes, C.; Coimbra, M.A.; Reis, R.L.; Martins, A.; Wang, C.; Silva, T.H.; et al. Fucoidan from Fucus vesiculosus Inhibits Inflammatory Response, Both In Vitro and In Vivo. Mar. Drugs 2023, 21, 302. https://doi.org/10.3390/md21050302 |
Resumo(s): | Fucoidan has been reported to present diverse bioactivities, but each extract has specific features from which a particular biological activity, such as immunomodulation, must be confirmed. In this study a commercially available pharmaceutical-grade fucoidan extracted from Fucus vesiculosus, FE, was characterized and its anti-inflammatory potential was investigated. Fucose was the main monosaccharide (90 mol%) present in the studied FE, followed by uronic acids, galactose, and xylose that were present at similar values (3.8–2.4 mol%). FE showed a molecular weight of 70 kDa and a sulfate content of around 10%. The expression of cytokines by mouse bone-marrow-derived macrophages (BMDMs) revealed that the addition of FE upregulated the expression of CD206 and IL-10 by about 28 and 22 fold, respectively, in respect to control. This was corroborated in a stimulated pro-inflammatory situation, with the higher expression (60 fold) of iNOS being almost completely reversed by the addition of FE. FE was also capable of reverse LPS-caused inflammation in an in vivo mouse model, including by reducing macrophage activation by LPS from 41% of positive CD11C to 9% upon fucoidan injection. Taken together, the potential of FE as an anti-inflammatory agent was validated, both in vitro and in vivo. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/85642 |
DOI: | 10.3390/md21050302 |
e-ISSN: | 1660-3397 |
Versão da editora: | https://www.mdpi.com/1660-3397/21/5/302 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
marinedrugs-21-00302.pdf | 2,35 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons