Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/85426
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Pastrez, Paula Roberta Aguiar | por |
dc.contributor.author | Barbosa, Ana Margarida | por |
dc.contributor.author | Mariano, Vânia Sammartino | por |
dc.contributor.author | Causin, Rhafaela Lima | por |
dc.contributor.author | Castro, António G. | por |
dc.contributor.author | Torrado, Egídio | por |
dc.contributor.author | Longatto, Adhemar | por |
dc.date.accessioned | 2023-07-06T17:25:24Z | - |
dc.date.available | 2023-07-06T17:25:24Z | - |
dc.date.issued | 2023-03-27 | - |
dc.identifier.citation | Pastrez, P.R.A.; Barbosa, A.M.; Mariano, V.S.; Causin, R.L.; Castro, A.G.; Torrado, E.; Longatto-Filho, A. Interleukin-8 and Interleukin-6 Are Biomarkers of Poor Prognosis in Esophageal Squamous Cell Carcinoma. Cancers 2023, 15, 1997. https://doi.org/10.3390/cancers15071997 | por |
dc.identifier.uri | https://hdl.handle.net/1822/85426 | - |
dc.description.abstract | Esophageal squamous cell carcinoma (ESCC) is a common type of cancer characterized by fast progression and high mortality rates, which generally implies a poor prognosis at time of diagnosis. Intricate interaction networks of cytokines produced by resident and inflammatory cells in the tumor microenvironment play crucial roles in ESCC development and metastasis, thus influencing therapy efficiency. As such, cytokines are the most prominent targets for specific therapies and prognostic parameters to predict tumor progression and aggressiveness. In this work, we examined the association between ESCC progression and the systemic levels of inflammatory cytokines to determine their usefulness as diagnostic biomarkers. We analyzed the levels of IL-1β, IL-6, IL-8, IL-10, TNF-α e IL-12p70 in a group of 70 ESCC patients and 70 healthy individuals using Cytometric Bead Array (CBA) technology. We detected increased levels of IL-1β, IL-6, IL-8, and IL-10 in ESCC patients compared to controls. However, multivariate analysis revealed that only IL8 was an independent prognostic factor for ESCC, as were the well-known risk factors: alcohol consumption, tobacco usage, and exposure to pesticides/insecticides. Importantly, patients with low IL-6, IL-8, TNM I/II, or those who underwent surgery had a significantly higher overall survival rate. We also studied cultured Kyse-30 and Kyse-410 cells in mice. We determined that the ESCC cell line Kyse-30 grew more aggressively than the Kyse-410 cell line. This enhanced growth was associated with the recruitment/accumulation of intratumoral polymorphonuclear leukocytes. In conclusion, our data suggest IL-8 as a valuable prognostic factor with potential as a biomarker for ESCC. | por |
dc.description.sponsorship | The authors appreciate the financial support of Capes/PDSE (number of process 88881.135146/2016-01), Barretos Cancer Hospital, Foundation for Science and Technology (FCT) projects PTDC/MED-ONC/28658/2017, UIDB/50026/2020 and UIDP/50026/2020. This study was also partially supported by PublicMinistry of Labor Campinas (Research, Prevention and Education of Occupational Cancer, Brazil) and by the project NORTE-01-0145-FEDER-000055, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). A.M.B. and E.T. were supported by FCT, the fellowship SFRH/BD/120371/2016, and Estímulo Individual ao Emprego Científico CEECIND/03070/2020, respectively. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute | por |
dc.relation | 88881.135146/2016-01 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMED-ONC%2F28658%2F2017/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50026%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50026%2F2020/PT | por |
dc.relation | NORTE-01-0145-FEDER-000055 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F120371%2F2016/PT | por |
dc.relation | CEECIND/03070/2020 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Cytokines | por |
dc.subject | Tumor microenvironment | por |
dc.subject | Sophageal cancer | por |
dc.subject | Inflammation | por |
dc.subject | Interleukin-8 | por |
dc.subject | Interleukin-6 | por |
dc.subject | esophageal cancer | por |
dc.title | Interleukin-8 and Interleukin-6 are biomarkers of poor prognosis in Esophageal squamous cell carcinoma | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2072-6694/15/7/1997 | por |
oaire.citationIssue | 7 | por |
oaire.citationVolume | 15 | por |
dc.date.updated | 2023-04-12T13:24:32Z | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.doi | 10.3390/cancers15071997 | por |
dc.subject.fos | Ciências Médicas::Outras Ciências Médicas | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Cancers | por |
oaire.version | VoR | por |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
cancers-15-01997.pdf | 2,44 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons