Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/85297
Título: | Analysis of salivary levels of IL-1β, IL17A, OPG and RANK-L in periodontitis using the 2017 Classification of Periodontal Diseases - an exploratory observational study |
Autor(es): | Relvas, Marta Silvestre, Ricardo Jorge Leal Gonçalves, Maria Cabral, Cristina Frias, Ana Isabel Mendes Monteiro, Luís Viana da Costa, Alexandra |
Palavras-chave: | Periodontitis Saliva IL-1β RANK-L OPG IL17-A Biomarkers Grade Stage IL-1 beta |
Data: | 28-Jan-2023 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Journal of Clinical Medicine |
Citação: | Relvas, M.; Silvestre, R.; Gonçalves, M.; Cabral, C.; Mendes-Frias, A.; Monteiro, L.; Viana da Costa, A. Analysis of Salivary Levels of IL-1β, IL17A, OPG and RANK-L in Periodontitis Using the 2017 Classification of Periodontal Diseases—An Exploratory Observational Study. J. Clin. Med. 2023, 12, 1003. https://doi.org/10.3390/jcm12031003 |
Resumo(s): | Periodontitis is a chronic disease with a high overall prevalence. It involves a complex interplay between the immune-inflammatory pathways and biofilm changes, leading to periodontal attachment loss. The aims of this study were (i) to assess whether the salivary IL-1β, IL-17A, RANK-L and OPG levels have the potential to discriminate between the mild and severe periodontitis conditions; and (ii) to enable diagnostic/prognostic actions to differentiate between distinct levels of the disease. The analysis of the clinical parameters and the evaluation of the salivary immunomediators levels by means of a multiplex flow assay revealed a statistically significantly higher level of IL-1β in the periodontitis III/IV patients, as well as a higher level of RANK-L in the periodontitis III/IV and I/II patients, when compared to the healthy controls. Furthermore, the grade C periodontitis patients presented a significantly higher level of RANK-L compared to the grade B and grade A patients. In the grade C patients, IL-1β had a positive correlation with the PPD and CAL indices and RANK_L had a positive correlation with CAL. The evidence emerging from this study associates the salivary IL-1β and RANK-L levels with an advanced stage of periodontitis, stage III/IV, and with grade C, suggesting the possible cooperative action of both in the inflammatory and bone loss events. In addition to IL-1β, RANK-L could be considered a combined diagnostic biomarker for periodontitis. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/85297 |
DOI: | 10.3390/jcm12031003 |
e-ISSN: | 2077-0383 |
Versão da editora: | https://www.mdpi.com/2077-0383/12/3/1003 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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jcm-12-01003.pdf | 505,05 kB | Adobe PDF | Ver/Abrir |
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