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https://hdl.handle.net/1822/84992
Título: | Non-canonical amino acids as building blocks for peptidomimetics: structure, function, and applications |
Autor(es): | Castro, Tarsila Gabriel Melle-Franco, Manuel Sousa, Cristina E. A. Cavaco-Paulo, Artur Marcos, João Carlos |
Palavras-chave: | Non-canonical amino acids Side-chain modifications Backbone modifications Peptidomimetics Foldamers Structure-function relationship |
Data: | 12-Jun-2023 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Biomolecules |
Citação: | Castro, T.; Melle-Franco, Manuel; Sousa, Cristina; Cavaco-Paulo, Artur; Marcos, João C., Non-canonical amino acids as building blocks for peptidomimetics: structure, function, and applications. Biomolecules, 13(6), 981, 2023 |
Resumo(s): | This review provides a fresh overview of non-canonical amino acids and their applications in the design of peptidomimetics. Non-canonical amino acids appear widely distributed in nature and are known to enhance the stability of specific secondary structures and/or biological function. Contrary to the ubiquitous DNA-encoded amino acids, the structure and function of these residues are not fully understood. Here, results from experimental and molecular modelling approaches are gathered to classify several classes of non-canonical amino acids according to their ability to induce specific secondary structures yielding different biological functions and improved stability. Regarding side-chain modifications, symmetrical and asymmetrical α,α-dialkyl glycines, Cα to Cα cyclized amino acids, proline analogues, β-substituted amino acids, and α,β-dehydro amino acids are some of the non-canonical representatives addressed. Backbone modifications were also examined, especially those that result in retro-inverso peptidomimetics and depsipeptides. All this knowledge has an important application in the field of peptidomimetics, which is in continuous progress and promises to deliver new biologically active molecules and new materials in the near future. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/84992 |
DOI: | 10.3390/biom13060981 |
ISSN: | 2218-273X |
Versão da editora: | https://www.mdpi.com/2218-273X/13/6/981 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_56283_1.pdf | 3,93 MB | Adobe PDF | Ver/Abrir |