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https://hdl.handle.net/1822/84523
Título: | Extensional flow for assessing the effect of nanocarriers on the mechanical deformability of red blood cells |
Autor(es): | Kriebel, Jana Gonçalves, Inês Maia Silva Rodrigo Baptista, Vitória Cunha Veiga, Maria Isabel Minas, Graça Lima, Rui Catarino, Susana Oliveira |
Palavras-chave: | Deformation index Microfluidics Nanoparticles Red blood cells Extensional flow velocity |
Data: | 23-Abr-2023 |
Editora: | Elsevier 1 |
Revista: | Experimental Thermal and Fluid Science |
Citação: | Jana Kriebel, Inês M. Gonçalves, Vitória Baptista, Maria I. Veiga, Graça Minas, Rui Lima, Susana O. Catarino, Extensional flow for assessing the effect of nanocarriers on the mechanical deformability of red blood cells, Experimental Thermal and Fluid Science, Vol 146, August 2023, 110931 (doi: 10.1016/j.expthermflusci.2023.110931) |
Resumo(s): | The effect of nanoparticles on the mechanical behavior of red blood cells (RBCs) under an extensional flow has not been extensively studied. In this work, by using a microfluidic hyperbolic contraction, it is assessed the deformability of healthy RBCs in contact with ∼20 nm nanoparticles of magnetic iron and non-magnetic cerium. The results showed that, under a controlled extensional flow, the healthy RBCs deformability index depended on the cells’ velocity along the microfluidic contraction. Additionally, the results showed that the deformability index of the RBCs decreased when the cells got in contact with the nanoparticles, being that difference higher for the magnetic nanoparticles and for the longer exposition times. The RBCs presented a logarithmic deformability index vs velocity trend, with variations according to the magnetic or non-magnetic properties of the nanoparticles, to the concentration and to the exposure time. Thus, the representation of the deformation index as a function of velocity seems to be a promising method to evaluate the mechanical behavior of the cells. Such knowledge will be essential for further understanding how the cell-nanoparticle interactions occur in RBCs disorders, and will open new possibilities regarding future applications of these nanocarriers in targeted drug delivery systems for therapeutics. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/84523 |
DOI: | 10.1016/j.expthermflusci.2023.110931 |
ISSN: | 0894-1777 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0894177723000870 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CMEMS - Artigos em revistas internacionais/Papers in international journals MEtRICs - Artigos em revistas internacionais/Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1-s2.0-S0894177723000870-main.pdf | Article | 6,93 MB | Adobe PDF | Ver/Abrir |
1-s2.0-S0894177723000870-supplementary material.pdf | Supplementary material | 1,79 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons