Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/83706
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Campo DC | Valor | Idioma |
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dc.contributor.author | Maia, Renata Patrícia Faria | por |
dc.contributor.author | Carvalho, Violeta Meneses | por |
dc.contributor.author | Lima, Rui | por |
dc.contributor.author | Minas, Graça | por |
dc.contributor.author | Rodrigues, Raquel Oliveira | por |
dc.date.accessioned | 2023-03-31T14:29:32Z | - |
dc.date.available | 2023-03-31T14:29:32Z | - |
dc.date.issued | 2023-02-28 | - |
dc.identifier.citation | Maia, R.; Carvalho, V.; Lima, R.; Minas, G.; Rodrigues, R.O. Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications. Pharmaceutics 2023, 15, 792. https://doi.org/10.3390/ pharmaceutics15030792 | por |
dc.identifier.uri | https://hdl.handle.net/1822/83706 | - |
dc.description.abstract | Microneedles (MNs) have been widely used in biomedical applications for drug delivery and biomarker detection purposes. Furthermore, MNs can also be used as a stand-alone tool to be combined with microfluidic devices. For that purpose, lab- or organ-on-a-chip are being developed. This systematic review aims to summarize the most recent progress in these emerging systems, to identify their advantages and limitations, and discuss promising potential applications of MNs in microfluidics. Therefore, three databases were used to search papers of interest, and their selection was made following the guidelines for systematic reviews proposed by PRISMA. In the selected studies, the MNs type, fabrication strategy, materials, and function/application were evaluated. The literature reviewed showed that although the use of MNs for lab-on-a-chip has been more explored than for organ-on-a-chip, some recent studies have explored this applicability with great potential for the monitoring of organ models. Overall, it is shown that the presence of MNs in advanced microfluidic devices can simplify drug delivery and microinjection, as well as fluid extraction for biomarker detection by using integrated biosensors, which is a promising tool to precisely monitor, in real-time, different kinds of biomarkers in lab- and organ-on-a-chip platforms. | por |
dc.description.sponsorship | This work was supported by the project EXPL/EMD-EMD/0650/2021, and partially supported by the project PTDC/EEI-EEE/2846/2021, through national funds (OE), within the scope of the Scientific Research and Technological Development Projects (IC&DT) program in all scientific domains (PTDC), through the Foundation for Science and Technology, I.P. (FCT, I.P). This project also received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 101032481. V.C. is grateful for her Ph.D. grant from Fundação para a Ciência e Tecnologia (FCT) with reference UI/BD/151028/2021 and Fulbright Grant for Research with the support of FCT, AY2022/2023. R.O.R. thanks FCT for her contract funding provided through 2020.03975.CEECIND. The authors also acknowledge the partial financial support within the R&D Unit Project Scope: UIDB/04436/2020, UIDB/04077/2020, UIDB/00532/2020, LA/P/0045/2020. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FEMD-EMD%2F0650%2F2021/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEEI-EEE%2F2846%2F2021/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/OE/UI%2FBD%2F151028%2F2021/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04436%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04077%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00532%2F2020/PT | por |
dc.relation | LA/P/0045/2020 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Microfluidic | por |
dc.subject | Microneedles | por |
dc.subject | Organ-on-a-chip | por |
dc.subject | Lab-on-a-chip | por |
dc.subject | Drug screening | por |
dc.subject | Biomarkers detection | por |
dc.title | Microneedles in advanced microfluidic systems: a systematic review throughout lab and organ-on-a-chip applications | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/15/3/792 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 19 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 15 | por |
dc.identifier.eissn | 1999-4923 | - |
dc.identifier.doi | 10.3390/pharmaceutics15030792 | por |
dc.subject.fos | Engenharia e Tecnologia::Engenharia Médica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Pharmaceutics | por |
oaire.version | VoR | por |
dc.identifier.articlenumber | 792 | por |
dc.subject.ods | Saúde de qualidade | por |
Aparece nas coleções: | CMEMS - Artigos em revistas internacionais/Papers in international journals MEtRICs - Artigos em revistas internacionais/Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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pharmaceutics-15-00792.pdf | Artigo Publicado | 2,74 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons