Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/83031
Título: | CMOS spectrophotometric microsystem for malaria detection |
Autor(es): | Ferreira, Gabriel Malheiro Baptista, Vitória Silva, Vitor Veiga, Maria I. Minas, Graça Catarino, Susana Oliveira |
Palavras-chave: | Cadence IC tools CMOS Light to frequency converters Malaria parasite Optical spectrophotometry Biomedical optical imaging Diseases Micromechanical devices Optical device fabrication Optical filters Optical reflection Photodiodes |
Data: | 6-Fev-2023 |
Editora: | Institute of Electrical and Electronics Engineers (IEEE) |
Revista: | IEEE Transactions on Biomedical Engineering |
Citação: | G. M. Ferreira, V. Baptista, V. Silva, M. I. Veiga, G. Minas and S. O. Catarino, "CMOS spectrophotometric microsystem for malaria detection," in IEEE Transactions on Biomedical Engineering, doi: 10.1109/TBME.2023.3242691. |
Resumo(s): | Objectives: Optical spectrophotometry has been explored to quantify Plasmodium falciparum malaria parasites at low parasitemia, with potential to overcome the limitations of detection in the current diagnostic methods. This work presents the design, simulation and fabrication of a CMOS microelectronic detection system to automatically quantify the presence of malaria parasites in a blood sample. Methods: The designed system is composed by an array of 16 n+/p-substrate silicon junction photodiodes as photodetectors and 16 current to frequency (IF) converters. An optical setup was used to individually and jointly characterize the entire system. Results: The IF converter was simulated and characterized in Cadence Tools using UMC 1180 MM/RF technology rules, featuring a resolution of 0.01 nA, a linearity up to 1800 nA and a sensitivity of 4430 Hz/nA. After fabrication in a silicon foundry, the photodiodes' characterization presented a responsivity peak of 120 mA/W (λ = 570 nm) and a dark current of 7.15 pA at 0 V. Regarding the IF converter, it exhibited high linearity (R2 ≈ 0.999) up to 30 nA, with a sensitivity of 4840 Hz/nA. Furthermore, the microsystem performance was validated using RBCs (Red Blood Cells) infected with P. falciparum and diluted at different parasitemia (12, 25 and 50 parasites/μL). Conclusion: The microsystem was able to distinguish between healthy and infected RBCs, with a sensitivity of 4.5 Hz/parasites.μL -1 . Significance: The developed microsystem presents a competitive result, when compared to the gold standard diagnosis methods, with increased potential for malaria in field diagnosis. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/83031 |
DOI: | 10.1109/TBME.2023.3242691 |
ISSN: | 0018-9294 |
e-ISSN: | 1558-2531 |
Versão da editora: | https://ieeexplore.ieee.org/document/10038491 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CMEMS - Artigos em revistas internacionais/Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Early Access - CMOS_spectrophotometric_microsystem_for_malaria_detection.pdf Acesso restrito! | Early access version | 1,11 MB | Adobe PDF | Ver/Abrir |