Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/82504
Título: | Electrochemical characterization of imidazole-based carboxamidrazones in aqueous and organic solutions and structure-activity relationship |
Autor(es): | Rodrigues, Rui Pedro Vieira Dantas, Daniela Filipa Costa Carvalho, André Filipe Couto Ribeiro, Ana Isabel Ferreira Zille, Andrea Silva, Renata Remião, Fernando Dias, Alice Pinto, Eugénia Cerqueira, Fátima Geraldo, Dulce |
Data: | 2022 |
Resumo(s): | The search for new antibiotics is an emergent topic in the scientific community due to the appearance of pathogenic organisms multiresistant to the available drugs and therapy [1]. The worrying increase in infections caused by pathogenic fungi in immunosuppressed patients prompted the search for new antifungal agents with new mechanisms of action and less side effects [2]. The imidazole ring is a crucial scaffold for drug design due to its vital role in various biological processes [3]. Thus, imidazole-based molecules have been widely used to synthetize promising heterocyclic ligands for several drug targets. Furthermore, amidrazones are known for their high reactivity, being useful intermediates for the synthesis of compounds with a wide range of biological activities, including antimicrobial action. The amidrazone derivatives have also been applied in different areas of chemistry, specifically in the synthesis of azo molecules [4]. In a previous work, novel imidazole based 5-aminoimidazole-4-carboxamidrazones were synthesized, which exhibited great antifungal activity evaluated against three yeast species, namely Candida krusei, Candida albicans and Candida parapsilosis [5]. In this communication, the electrochemical characterization of some carboxamidrazones performed by cyclic voltammetry in two different media is compared. The effects of substituent groups in the different carboxamidrazones on the variation of oxidation potential of these compounds in aqueous and organic media were also analyzed. To find a relationship between chemical structure and activity, the minimum inhibitory concentration was correlated with their oxidation potentials. The effect of the variation of pH on the oxidation potential of substituted carboxamidrazones was also analyzed. In addition, kinetic studies of the evolution of some carboxamidrazones in aqueous media characterized by UV-Vis spectroscopy were performed and the obtained results were correlated with the electrochemical and biological data. |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/82504 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings DET/2C2T - Comunicações em congressos nacionais com arbitragem científica |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Abstract_VIETCAQ.pdf | 111,93 kB | Adobe PDF | Ver/Abrir |