Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/82222
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Campo DC | Valor | Idioma |
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dc.contributor.author | Gonçalves, Inês M. | por |
dc.contributor.author | Rodrigues, Raquel Oliveira | por |
dc.contributor.author | Moita, Ana S. | por |
dc.contributor.author | Hori, Takeshi | por |
dc.contributor.author | Kaji, Hirokazu | por |
dc.contributor.author | Lima, Rui Alberto Madeira Macedo | por |
dc.contributor.author | Minas, Graça | por |
dc.date.accessioned | 2023-01-25T14:18:16Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Gonçalves, I. M., Rodrigues, R. O., Moita, A. S., Hori, T., Kaji, H., Lima, R. A., & Minas, G. (2022, June). Recent trends of biomaterials and biosensors for organ-on-chip platforms. Bioprinting. Elsevier BV. http://doi.org/10.1016/j.bprint.2022.e00202 | por |
dc.identifier.issn | 2405-8866 | por |
dc.identifier.uri | https://hdl.handle.net/1822/82222 | - |
dc.description.abstract | Organ-on-chip (OoC) platforms are a new class of advanced microfluidic devices that have been attracting significant attention for drug development since they can allow a faster and more patient specific evaluation of the effects of drugs due to the mimicking of organ human models. As most microfluidic devices, the great majority of the OoC is made from polydimethylsiloxane (PDMS), due to the easiness to handle and due to its physicochemical properties. Nevertheless, PDMS can leach uncrosslinked oligomer and absorb small hydrophobic molecules, which makes it less suitable for cell culture. In this work, we review different kinds of materials that are used together with, or in replacement, of PDMS to manufacture the OoC platforms. Several studies have replicated differentiated structures and their key physiological functions, such as muscle contraction, skin elasticity and deformability, gas exchange in alveolar sacs, electrical stimulation or even to monitor the microenvironment, inside the chip. Therefore, in this Review, recent advances on OoC platforms, including fabrication and miniaturization of biosensors for an end-use perspective are revised. | por |
dc.description.sponsorship | This work has been supported by the projects NORTE-01-0145-FEDER-030171 (project reference PTDC/EME-SIS/30171/2017), NORTE-01-0145-FEDER-029394 (project reference PTDC/EMD-EMD/ 29394/2017), through the COMPETE2020, the Lisb@2020, the Programa Operacional Regional do Norte–Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (FEDER) and by Fundação para a Ciência e Tecnologia (FCT), and through FEDER and FCT, project references EXPL/EMD-EMD/0650/2021 and PTDC/EEI-EEE/2846/2021. The authors also acknowledge the partial financial support within the R&D Units Project Scope: UIDB/00319/2020, UIDB/04077/2020, UIDB/00690/2020, UIDB/04436/2020, BD/08646/2020. This work was also funded by AMED-CREST Grant Number JP21gm1310001h0002. Raquel O. Rodrigues (R.O.R.) thanks FCT for her contract funding provided through 2020.03975.CEECIND. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEEI-EEE%2F2846%2F2021/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FEMD-EMD%2F0650%2F2021/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FEMD-EMD%2F29394%2F2017/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FEME-SIS%2F30171%2F2017/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Organ-on-a-chip | por |
dc.subject | Biomaterials | por |
dc.subject | PDMS | por |
dc.subject | Biosensors | por |
dc.subject | Hydrogel | por |
dc.subject | PMMA | por |
dc.title | Recent trends of biomaterials and biosensors for organ-on-chip platforms | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2405886622000124 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 16 | por |
oaire.citationVolume | 26 | por |
dc.identifier.eissn | 2405-8866 | - |
dc.identifier.doi | 10.1016/j.bprint.2022.e00202 | por |
dc.date.embargo | 10000-01-01 | - |
dc.subject.fos | Engenharia e Tecnologia::Engenharia Médica | por |
sdum.journal | Bioprinting | por |
oaire.version | VoR | por |
dc.identifier.articlenumber | e00202 | por |
dc.subject.ods | Saúde de qualidade | por |
Aparece nas coleções: | CMEMS - Artigos em revistas internacionais/Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1-s2.0-S2405886622000124-main.pdf Acesso restrito! | Final Paper | 8,35 MB | Adobe PDF | Ver/Abrir |