Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/82219
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Carvalho, Violeta Meneses | por |
dc.contributor.author | Bañobre-López, Manuel | por |
dc.contributor.author | Minas, Graça | por |
dc.contributor.author | Teixeira, S. F. C. F. | por |
dc.contributor.author | Lima, Rui Alberto Madeira Macedo | por |
dc.contributor.author | Rodrigues, Raquel Oliveira | por |
dc.date.accessioned | 2023-01-25T14:09:14Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Carvalho, V., Bañobre-López, M., Minas, G., Teixeira, S. F. C. F., Lima, R., & Rodrigues, R. O. (2022, August). The integration of spheroids and organoids into organ-on-a-chip platforms for tumour research: A review. Bioprinting. Elsevier BV. http://doi.org/10.1016/j.bprint.2022.e00224 | por |
dc.identifier.issn | 2405-8866 | por |
dc.identifier.uri | https://hdl.handle.net/1822/82219 | - |
dc.description.abstract | Every year, cancer causes millions of deaths around the globe, and researchers have been engaged to provide novel therapies for this threatening disease. However, this process is commonly hampered by failures in clinical trials. For this reason, efforts have been made to develop in vitro models capable of modelling the complex and heterogeneous tumour microenvironment, giving rise to organ-on-a-chip platforms. These devices have been paramount for further advancements in cancer research by providing a physiologically relevant platform with tumour organ-specificity. Organ-on-a-chip technology combines biomaterials, tissue engineering, oncology, and pharmacology in one device, making this a promising alternative to in vivo testing. This work reviews the progress made in organ-on-a-chip and multi-organ-on-a-chip models toward cancer research and provides an overview of the cells used, the 3D culture models developed and the materials selected to fabricate the microfluidic devices | por |
dc.description.sponsorship | Violeta Carvalho thank for her Ph.D. grant from FCT with reference UI/BD/151028/2021. Raquel O. Rodrigues thanks FCT for her contract funding provided through 2020.03975.CEECIND. This work has been also supported by the projects, EXPL/EMD-EMD/0650/2021, PTDC/ EMD-EMD/29394/2017 and PTDC/EEI-EEE/2846/2021 through the COMPETE2020, under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (FEDER) and by Fundação para a Ciência e Tecnologia (FCT). The authors also acknowledge the partial financial support within the R&D Units Project Scope: UIDB/00319/2020, UIDB/04077/2020, UIDB/04436/2020, UIDB/00532/2020. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEEI-EEE%2F2846%2F2021/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FEMD-EMD%2F0650%2F2021/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FEMD-EMD%2F29394%2F2017/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/OE/UI%2FBD%2F151028%2F2021/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00319%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04077%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04436%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00532%2F2020/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Organ-on-a-chip | por |
dc.subject | Cancer research | por |
dc.title | The integration of spheroids and organoids into organ-on-a-chip platforms for tumour research: a review | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2405886622000343 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 15 | por |
oaire.citationVolume | 27 | por |
dc.identifier.eissn | 2405-8866 | - |
dc.identifier.doi | 10.1016/j.bprint.2022.e00224 | por |
dc.date.embargo | 10000-01-01 | - |
dc.subject.fos | Engenharia e Tecnologia::Engenharia Médica | por |
sdum.journal | Bioprinting | por |
oaire.version | VoR | por |
dc.identifier.articlenumber | e00224 | por |
dc.subject.ods | Saúde de qualidade | por |
Aparece nas coleções: | CMEMS - Artigos em revistas internacionais/Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1-s2.0-S2405886622000343-main.pdf Acesso restrito! | Final paper | 4,77 MB | Adobe PDF | Ver/Abrir |