Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/81321
Título: | The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models |
Autor(es): | Teixeira, Silvia A. Luzzi, Mayara de Cassia Martin, Ana Carolina Baptista Moreno Duarte, Terence Teixeira Leal, Mônica de Oliveira Teixeira, Gustavo Ramos Reis, Monise Tadin Junior, Carlos Roberto Almeida Santos, Karina Melendez, Matias Eliseo Silva, Diego da Cunha Silveira Alves da Bernécule, Priscila Neves Firmino, Higor Vinicius Lourenço Alves, Ana Laura Vieira Guimarães, Denise Peixoto Borduqui, João Vitor Laus, Ana Carolina Mançano, Bruna Minniti Reis, R. M. |
Palavras-chave: | PTCH1-knockout Apc<sup>Min</sup> xenografts PDX genetically engineered mouse models personalized therapy tumor biology Apc(Min) |
Data: | 16-Nov-2022 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Veterinary Sciences |
Citação: | Teixeira, S.A.; Luzzi, M.d.C.; Martin, A.C.B.M.; Duarte, T.T.; Leal, M.d.O.; Teixeira, G.R.; Reis, M.T.; Junior, C.R.A.; Santos, K.; Melendez, M.E.; Silva, D.d.C.S.A.d.; Bernécule, P.N.; Firmino, H.V.L.; Alves, A.L.V.; Guimarães, D.P.; Borduqui, J.V.; Laus, A.C.; Mançano, B.M.; Reis, R.M. The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models. Vet. Sci. 2022, 9, 636. https://doi.org/10.3390/vetsci9110636 |
Resumo(s): | The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and <i>Apc<sup>Min</sup></i> mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/81321 |
DOI: | 10.3390/vetsci9110636 |
e-ISSN: | 2306-7381 |
Versão da editora: | https://www.mdpi.com/2306-7381/9/11/636 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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vetsci-09-00636-v2.pdf | 4,17 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons