Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/80814
Título: | Magnetic micellar nanovehicles: prospects of multifunctional hybrid systems for precision theranostics |
Autor(es): | Miranda, Margarida Silva Almeida, Ana Filipa Martins Gomes, Manuela E. Rodrigues, Márcia T. |
Palavras-chave: | Hybrid nanosystems Magnetic polymeric micelles Polymeric micelles Magnetic nanoparticles Imaging Drug delivery Target delivery Nanotherapeutics Hyperthermia Magnetically assisted technologies |
Data: | 4-Out-2022 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | International Journal of Molecular Sciences |
Citação: | Miranda, M.S.; Almeida, A.F.; Gomes, M.E.; Rodrigues, M.T. Magnetic Micellar Nanovehicles: Prospects of Multifunctional Hybrid Systems for Precision Theranostics. Int. J. Mol. Sci. 2022, 23, 11793. https://doi.org/10.3390/ijms231911793 |
Resumo(s): | Hybrid nanoarchitectures such as magnetic polymeric micelles (MPMs) are among the most promising nanotechnology-enabled materials for biomedical applications combining the benefits of polymeric micelles and magnetic nanoparticles within a single bioinstructive system. MPMs are formed by the self-assembly of polymer amphiphiles above the critical micelle concentration, generating a colloidal structure with a hydrophobic core and a hydrophilic shell incorporating magnetic particles (MNPs) in one of the segments. MPMs have been investigated most prominently as contrast agents for magnetic resonance imaging (MRI), as heat generators in hyperthermia treatments, and as magnetic-susceptible nanocarriers for the delivery and release of therapeutic agents. The versatility of MPMs constitutes a powerful route to ultrasensitive, precise, and multifunctional diagnostic and therapeutic vehicles for the treatment of a wide range of pathologies. Although MPMs have been significantly explored for MRI and cancer therapy, MPMs are multipurpose functional units, widening their applicability into less expected fields of research such as bioengineering and regenerative medicine. Herein, we aim to review published reports of the last five years about MPMs concerning their structure and fabrication methods as well as their current and foreseen expectations for advanced biomedical applications. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/80814 |
DOI: | 10.3390/ijms231911793 |
ISSN: | 1661-6596 |
e-ISSN: | 1422-0067 |
Versão da editora: | https://www.mdpi.com/1422-0067/23/19/11793 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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ijms-23-11793-v2.pdf | 9,1 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons