Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/80677
Título: | Hyaluronan receptors as mediators and modulators of the tumor microenvironment |
Autor(es): | Carvalho, Ana M. Reis, R. L. Pashkuleva, I. |
Palavras-chave: | Hyaladherins CD44 RHAMM TLR2/4 LYVE-1 HARE/Stab2 Layilin HARE Stab2 TLR2 4 |
Data: | 2023 |
Editora: | John Wiley & Sons |
Revista: | Advanced Healthcare Materials |
Citação: | A. M. Carvalho, R. L. Reis, I. Pashkuleva, Hyaluronan Receptors as Mediators and Modulators of the Tumor Microenvironment. Adv. Healthcare Mater. 2023, 12, 2202118. https://doi.org/10.1002/adhm.202202118 |
Resumo(s): | The tumor microenvironment (TME) is a dynamic and complex matter shaped by heterogenous cancer and cancer-associated cells present at the tumor site. Hyaluronan (HA) is a major TME component that plays pro-tumorigenic and carcinogenic functions. These functions are mediated by different hyaladherins expressed by cancer and tumor-associated cells triggering downstream signaling pathways that determine cell fate and contribute to TME progression towards a carcinogenic state. Here, we review the interaction of HA with several cell-surface hyaladherins â CD44, RHAMM, TLR2 and 4, LYVE-1, HARE and layilin. We discuss the signaling pathways activated by these interactions and the respective response of different cell populations within the TME, and the modulation of the TME. Potential cancer therapies via targeting these interactions are also briefly discussed. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/80677 |
DOI: | 10.1002/adhm.202202118 |
ISSN: | 2192-2640 |
Versão da editora: | https://doi.org/10.1002/adhm.202202118 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
20862-adv-healthcare-materials-2022-carvalho-hyaluronan-receptors-mediators-and-modulators-tumor-microenvi.pdf | 2,53 MB | Adobe PDF | Ver/Abrir |