Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/80438
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Campo DC | Valor | Idioma |
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dc.contributor.author | Oliveira, Carlos Bruno Pereira | por |
dc.contributor.author | Gomes, Valéria | por |
dc.contributor.author | Ferreira, Paula M. T. | por |
dc.contributor.author | Martins, José A. | por |
dc.contributor.author | Jervis, Peter John | por |
dc.date.accessioned | 2022-11-04T14:06:58Z | - |
dc.date.available | 2022-11-04T14:06:58Z | - |
dc.date.issued | 2022-11-11 | - |
dc.date.submitted | 2022-10-25 | - |
dc.identifier.citation | Oliveira, C.B.P.; Gomes, V.; Ferreira, P.M.T.; Martins, J.A.; Jervis, P.J. Peptide-Based Supramolecular Hydrogels as Drug Delivery Agents: Recent Advances. Gels 2022, 8, 706. https://doi.org/10.3390/gels8110706 | por |
dc.identifier.uri | https://hdl.handle.net/1822/80438 | - |
dc.description.abstract | Supramolecular peptide hydrogels have many important applications in biomedicine, including drug delivery applications for the sustained release of therapeutic molecules. Targeted and selective drug administration is often preferential to systemic drug delivery, as it can allow reduced doses and can avoid the toxicity and side-effects caused by off-target binding. New discoveries are continually being reported in this rapidly developing field. In this review, we report the latest developments in supramolecular peptide-based hydrogels for drug delivery, focusing primarily on discoveries that have been reported in the last four years (2018–present). We address clinical points, such as peptide self-assembly and drug release, mechanical properties in drug delivery, peptide functionalization, bioadhesive properties and drug delivery enhancement strategies, drug release profiles, and different hydrogel matrices for anticancer drug loading and release. | por |
dc.description.sponsorship | This work was supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CQUM (UID/QUI/00686/2019). FCT, FEDER, PORTUGAL2020 and COMPETE2020 are also acknowledged for funding under research project PTDC/QUI-QOR/29015/2017 (POCI-01-0145-FEDER-029015). | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00686%2F2019/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QOR%2F29015%2F2017/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Hydrogel | por |
dc.subject | Peptide | por |
dc.subject | Drug delivery | por |
dc.subject | Controlled release | por |
dc.subject | Smart materials | por |
dc.subject | Biomaterials | por |
dc.subject | stimuli-responsive | por |
dc.subject | cancer therapy | por |
dc.subject | supramolecular | por |
dc.title | Peptide-based supramolecular hydrogels as drug delivery agents: recent advances | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2310-2861/8/11/706 | por |
oaire.citationIssue | 11 | por |
oaire.citationVolume | 8 | por |
dc.identifier.doi | 10.3390/gels8110706 | por |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Gels | por |
oaire.version | CVoR | por |
dc.identifier.articlenumber | 706 | por |
dc.subject.ods | Saúde de qualidade | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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gels-08-00706.pdf | 2,63 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons