Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/79807
Título: | In vitro cancer models: a closer look at limitations on translation |
Autor(es): | Antunes, Nina Kundu, Banani Kundu, Subhas C Reis, R. L. Correlo, V. M. |
Palavras-chave: | cancer 3D cancer models point-of-care modelling tool gap analysis commercialization |
Data: | 7-Abr-2022 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Bioengineering |
Citação: | Antunes, N.; Kundu, B.; Kundu, S.C.; Reis, R.L.; Correlo, V. In Vitro Cancer Models: A Closer Look at Limitations on Translation. Bioengineering 2022, 9, 166. https://doi.org/10.3390/bioengineering9040166 |
Resumo(s): | In vitro cancer models are envisioned as high-throughput screening platforms for potential new therapeutic discovery and/or validation. They also serve as tools to achieve personalized treatment strategies or real-time monitoring of disease propagation, providing effective treatments to patients. To battle the fatality of metastatic cancers, the development and commercialization of predictive and robust preclinical in vitro cancer models are of urgent need. In the past decades, the translation of cancer research from 2D to 3D platforms and the development of diverse in vitro cancer models have been well elaborated in an enormous number of reviews. However, the meagre clinical success rate of cancer therapeutics urges the critical introspection of currently available preclinical platforms, including patents, to hasten the development of precision medicine and commercialization of in vitro cancer models. Hence, the present article critically reflects the difficulty of translating cancer therapeutics from discovery to adoption and commercialization in the light of in vitro cancer models as predictive tools. The state of the art of in vitro cancer models is discussed first, followed by identifying the limitations of bench-to-bedside transition. This review tries to establish compatibility between the current findings and obstacles and indicates future directions to accelerate the market penetration, considering the niche market. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/79807 |
DOI: | 10.3390/bioengineering9040166 |
e-ISSN: | 2306-5354 |
Versão da editora: | https://www.mdpi.com/2306-5354/9/4/166 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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bioengineering-09-00166-v2.pdf | 1,3 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons