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https://hdl.handle.net/1822/76105
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Campo DC | Valor | Idioma |
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dc.contributor.author | Baldim, Iara | por |
dc.contributor.author | Oliveira, Wanderley P. | por |
dc.contributor.author | Rao, Rekha | por |
dc.contributor.author | Raghuvir, Singh | por |
dc.contributor.author | Mahant, Sheefali | por |
dc.contributor.author | Gama, F. M. | por |
dc.contributor.author | Souto, Eliana B. | por |
dc.date.accessioned | 2022-02-22T10:30:18Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Baldim, Iara; Oliveira, Wanderley P.; Rao, Rekha; Raghuvir, Singh; Mahant, Sheefali; Gama, F. M.; Souto, Eliana B., Chapter 5 - Biofate and cellular interactions of lipid nanoparticles. In Prashant Kesharwani and Kamalinder K. Singh, Nanoparticle Therapeutics - Production Technologies, Types of Nanoparticles, and Regulatory Aspects, Academic Press, 2022. ISBN: 978-0-12-820757-4, 211-246 | por |
dc.identifier.isbn | 978-0-12-820757-4 | por |
dc.identifier.uri | https://hdl.handle.net/1822/76105 | - |
dc.description.abstract | By definition, drug targeting and delivery is the process of delivering a drug molecule to a specific site where the pharmacological effect is desired. A targeted release may simplify the drug administration protocols and reduce the amount of drug necessary, thus improving the cost-effectiveness and reducing the side effects. A drug administered by intravenous injection distributes in the whole body, reaching organs, tissues and cells where it's action is not required, potentially causing harmful effects. Therefore targeting is essential for the drug to reach the necessary concentration for therapeutic efficacy, while minimizing the toxic and unwanted effects to other organs caused by random and uncontrolled bioactive action. Nowadays, most of the targetable controlled drug delivery systems are based on nanotechnology. High selectivity and specificity ensure the physical contact of the bioactive molecule with the physiological target only at the desired location of the body. Indeed, the development of highly selective and site-specific delivery systems capable of maintaining the optimal effect in a suitable time frame is one of the main challenges in nanotherapy. Desirable features in nanocarriers include biodegradability and biocompatibility, nonimmunogenicity and stability in the bloodstream. These features can be found in different nanosystems available, such as liposomes, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), nanogels, micelles, dendrimers, and so on. The surface area of a particulate system increases several orders of magnitude with the decrease of its size to nanometric scale, promoting higher interactions with the biological environment. | por |
dc.description.sponsorship | The authors would like to thank the financial support received from Portuguese Science and Technology Foundation (FCT/MCT) and from European Funds (PRODER/COMPETE) under the project references M-ERA-NET/0004/2015-PAIRED and UIDB/04469/2020, co-financed by FEDER, under the Partner ship Agreement PT2020. The authors also acknowledge CAPES (Coordenac¸a˜o de Aperfeic¸oamento de Pes soal de Nı´vel Superior) for the financial support and for the fellowship of the first author (88887.368385/2019-00). This study was also supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte | por |
dc.language.iso | eng | por |
dc.publisher | Academic Press | por |
dc.relation | M-ERA-NET/0004/2015-PAIRED | por |
dc.relation | UIDB/04469/2020 | por |
dc.rights | restrictedAccess | por |
dc.subject | Biofate | por |
dc.subject | Liposomes | por |
dc.subject | Solid lipid nanoparticles (SLN) | por |
dc.subject | Nanostructured lipid carriers (NLC) | por |
dc.subject | Nanogels | por |
dc.subject | Micelles | por |
dc.subject | Dendrimers | por |
dc.title | Biofate and cellular interactions of lipid nanoparticles | por |
dc.type | bookPart | por |
dc.peerreviewed | yes | - |
dc.relation.publisherversion | https://www.sciencedirect.com/book/9780128207574/nanoparticle-therapeutics | por |
dc.comments | CEB55011 | por |
oaire.citationStartPage | 211 | por |
oaire.citationEndPage | 246 | por |
dc.date.updated | 2022-02-21T22:36:59Z | - |
dc.identifier.doi | 10.1016/B978-0-12-820757-4.00015-6 | por |
dc.date.embargo | 10000-01-01 | - |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
sdum.bookTitle | Nanoparticle therapeutics: production technologies, types of nanoparticles, and regulatory aspects | por |
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