Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/75838
Título: | The future in sensing technologies for malaria surveillance: a review of hemozoin-based diagnosis |
Autor(es): | Baptista, Vitória Costa, Mariana S. Calçada, Carla Sofia Martins Silva, Miguel João Ferreira Gil, José Pedro Veiga, Maria Isabel Catarino, Susana Oliveira |
Palavras-chave: | Biomedical applications Biosensors Diagnosis Diagnostic devices Hemozoin Malaria Plasmodium Sensing technologies |
Data: | Nov-2021 |
Editora: | American Chemical Society |
Revista: | ACS Sensors |
Resumo(s): | Early and effective malaria diagnosis is vital to control the disease spread and to prevent the emergence of severe cases and death. Currently, malaria diagnosis relies on optical microscopy and immuno-rapid tests; however, these require a drop of blood, are time-consuming, or are not specific and sensitive enough for reliable detection of low-level parasitaemia. Thus, there is an urge for simpler, prompt, and accurate alternative diagnostic methods. Particularly, hemozoin has been increasingly recognized as an attractive biomarker for malaria detection. As the disease proliferates, parasites digest host hemoglobin, in the process releasing toxic haem that is detoxified into an insoluble crystal, the hemozoin, which accumulates along with infection progression. Given its magnetic, optical, and acoustic unique features, hemozoin has been explored for new label-free diagnostic methods. Thereby, herein, we review the hemozoin-based malaria detection methods and critically discuss their challenges and potential for the development of an ideal diagnostic device. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/75838 |
DOI: | 10.1021/acssensors.1c01750 |
ISSN: | 2379-3694 |
Versão da editora: | https://pubs.acs.org/doi/abs/10.1021/acssensors.1c01750 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals CMEMS - Artigos em revistas internacionais/Papers in international journals |
Ficheiros deste registo:
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Publication.pdf Acesso restrito! | 2,36 MB | Adobe PDF | Ver/Abrir |