Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/75272
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Esteruelas, G. | por |
dc.contributor.author | Halbaut, L. | por |
dc.contributor.author | García-Torra, V. | por |
dc.contributor.author | Espina, M. | por |
dc.contributor.author | Cano, A. | por |
dc.contributor.author | Ettcheto, M. | por |
dc.contributor.author | Camins, A. | por |
dc.contributor.author | Souto, Eliana B. | por |
dc.contributor.author | Luisa García, M. | por |
dc.contributor.author | Sánchez-López, E. | por |
dc.date.accessioned | 2022-01-06T17:11:36Z | - |
dc.date.issued | 2022-01-25 | - |
dc.identifier.citation | Esteruelas, G.; Halbaut, L.; García-Torra, V.; Espina, M.; Cano, A.; Ettcheto, M.; Camins, A.; Souto, Eliana B.; Luisa García, M.; Sánchez-López, E., Development and optimization of Riluzole-loaded biodegradable nanoparticles incorporated in a mucoadhesive in situ gel for the posterior eye segment. International Journal of Pharmaceutics, 612(121379), 2022 | por |
dc.identifier.issn | 0378-5173 | por |
dc.identifier.uri | https://hdl.handle.net/1822/75272 | - |
dc.description | Supplementary data to this article can be found online at https://doi.org/10.1016/j.ijpharm.2021.121379. | por |
dc.description.abstract | Riluzole-loaded PLGA nanoparticles (RLZ-NPs) were developed to improve the biopharmaceutical profile of RLZ after ocular administration. Moreover, RLZ-NPs were dispersed in an in situ gelling system (RLZ-NPs-Gel) for topical administration as a potential neuroprotective strategy against glaucoma. Formulations were optimized using the design of experiments approach. Characterization of the physicochemical and rheological properties, as well as interaction studies were carried out. To ensure RLZ-NPs-Gel ocular safety, the irritant potential was also evaluated in vitro and in vivo. Moreover, in vivo ocular biodistribution was also undertaken. Optimized RLZ-NPs showed an average size below 200 nm, an encapsulation efficiency greater than 90% and a negative surface charge. Interaction studies of RLZ-NPs showed that RLZ was dispersed in the polymeric matrix. RLZ-NPs-Gel possess a pseudoplastic behavior and a medium-low post-gelling viscosity to avoid discomfort after ocular application. Simultaneously, RLZ-NPs-Gel were able to increase RLZ-NPs contact with the ocular surface. Both formulations demonstrated the ability to be distributed in the posterior eye segment after 24 h of their application obtaining a more delayed distribution for RLZ-NPs-Gel. Therefore, a novel in situ gelling system able to disperse RLZ-NPs has been successfully developed as innovative neuroprotective strategy for potential topical treatment of glaucoma. | por |
dc.description.sponsorship | This project was funded by the Generalitat de Catalunya (grant number 2017 SGR 1477). Eliana B. Souto wishes to thank the Portuguese Science and Technology Foundation (FCT) from the Ministry of Science and Technology (MCTES) for the project UIDB/04469/2020 (CEB strategic fund), co-funded by European Funds (PRODER/COMPETE) and FEDER, under the Partnership Agreement PT2020. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | restrictedAccess | por |
dc.subject | Riluzole | por |
dc.subject | Glaucoma | por |
dc.subject | PLGA nanoparticles | por |
dc.subject | In situ gelling gel | por |
dc.subject | Gellan gum | por |
dc.title | Development and optimization of Riluzole-loaded biodegradable nanoparticles incorporated in a mucoadhesive in situ gel for the posterior eye segment | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.elsevier.com/locate/issn/03785173 | por |
dc.comments | CEB55104 | por |
oaire.citationConferencePlace | Netherlands | - |
oaire.citationVolume | 612 | por |
dc.date.updated | 2021-12-30T17:40:16Z | - |
dc.identifier.doi | 10.1016/j.ijpharm.2021.121379 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 34915146 | por |
dc.subject.fos | Ciências Naturais::Ciências Biológicas | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | International Journal of Pharmaceutics | por |
dc.identifier.articlenumber | 121379 | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_55104_1.pdf Acesso restrito! | 4,33 MB | Adobe PDF | Ver/Abrir |