Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74901
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Lopes, Soraia V. | por |
dc.contributor.author | Walczak, Piotr | por |
dc.contributor.author | Janowski, Miroslaw | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Silva-Correia, Joana | por |
dc.contributor.author | Oliveira, J. M. | por |
dc.date.accessioned | 2021-12-09T14:50:26Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2021-12 | - |
dc.identifier.citation | Lopes S. V., Walczak P., Janowski M., Reis R. L., Silva-Correia J., Oliveira J. M. Cytocompatible manganese dioxide-based hydrogel nanoreactors for MRI imaging, Materials Science & Engineering C, doi:10.1016/j.msec.2021.112575, 2021 | por |
dc.identifier.issn | 0928-4931 | por |
dc.identifier.uri | https://hdl.handle.net/1822/74901 | - |
dc.description.abstract | The application of nanoparticles in magnetic resonance imaging (MRI) has been greatly increasing, due to their advantageous properties such as nanoscale dimension and tuneability. In this context, manganese (Mn2+)-based nanoparticles have been greatly investigated, due to their valuable use as a contrast agent, improving signal intensity and specificity in MRI (manganese-enhanced MRI, MEMRI). Additionally, Mn2+ can act as scavengers of reactive oxygen species (ROS), commonly present in the inflammatory processes of neurodegenerative diseases. The aim of the present study was to develop nanoreactors, which can be used as contrast-agent in MEMRI. Several blends of methacrylated gellan gum (GG-MA) and hyaluronic acid (HA) were embedded with different types of manganese dioxide (MnO2) nanoparticles and further physico-chemically characterized. Dynamic light scattering, scanning electron microscopy, water uptake and degradation studies were performed. In vitro cytotoxicity of the different formulations was also evaluated using an immortalized rat fibroblast cell line L929, up to 72 h of culturing. Synthesized nanoparticles were obtained with an average size of 70 nm and round-shaped morphology. The stability of the different formulations of hydrogels was not affected by nanoparticles' concentration or HA ratio. The presence of synthesized MnO2 (MnO2_S) nanoparticles reduced hydrogels' cytocompatibility, whereas the commercially available type 1 (MnO2_C1) nanoparticles were less toxic to cells. Additionally, cell proliferation and viability were enhanced when a lower content of HA was present. Higher concentrations (75 and 100 ng/mL) of MnO2_S and MnO2_C1 nanoparticles did not negatively affected cell viability, whereas the opposite effect was observed for the commercial type 2 (MnO2_C2) nanoparticles. Further studies are required to evaluate the potential application of the most promising nanoreactors' formulations for combined application in MEMRI and as ROS scavengers. | por |
dc.description.sponsorship | The authors would like to acknowledge the financial support pro vided through the EC Funded project NanoTech4ALS (ENMed/0008/ 2015) and the funding provided under the projects FROnTHERA (No. NORTE-01-0145-FEDER-000023) and JUSThera (No. NORTE-01-0145- FEDER-000055), supported by Norte Portugal Regional Operational Programme (No. NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). The authors also thank the funding through the project 2IQBIONEURO (ref. 0624_2IQBIONEURO_6_E). S.V. Lopes thanks to the Portuguese Foundation for Science and Technology (FCT) for the PhD grant (SFRH/ BD/143954/2019). The FCT distinction to J. Silva-Correia (IF/00115/ 2015) under the Investigator FCT program is also greatly acknowledged. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/ENMed%2F0008%2F2015/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F143954%2F2019/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00115%2F2015%2FCP1294%2FCT0005/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Hydrogels | por |
dc.subject | Magnetic resonance imaging | por |
dc.subject | Manganese dioxide | por |
dc.subject | Methacrylated Gellan-gum | por |
dc.subject | Nanoparticles | por |
dc.subject | Reactive oxygen species | por |
dc.title | Cytocompatible manganese dioxide-based hydrogel nanoreactors for MRI imaging | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0928493121007153 | por |
dc.comments | http://3bs.uminho.pt/node/20635 | por |
oaire.citationVolume | 134 | por |
dc.date.updated | 2021-12-09T11:57:01Z | - |
dc.identifier.doi | 10.1016/j.msec.2021.112575 | por |
dc.date.embargo | 10000-01-01 | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Materials Science & Engineering: C Materials for Biological Applications | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20635-soraia-paper-1-s20-s0928493121007153-main.pdf Acesso restrito! | 4,09 MB | Adobe PDF | Ver/Abrir |