Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74754
Título: | 3D flow-focusing microfluidic biofabrication: one-chip-fits-all hydrogel fiber architectures |
Autor(es): | Guimarães, Carlos F. Gasperini, Luca Marques, A. P. Reis, R. L. |
Palavras-chave: | 3D Biological models Cancer models Hydrogel microfibers Tissue engineering Vascular fibers |
Data: | Jun-2021 |
Editora: | Elsevier 1 |
Revista: | Applied Materials Today |
Citação: | Guimarães, C. F., Gasperini, L., Marques, A. P., & Reis, R. L. (2021, June). 3D flow-focusing microfluidic biofabrication: One-chip-fits-all hydrogel fiber architectures. Applied Materials Today. Elsevier BV. http://doi.org/10.1016/j.apmt.2021.101013 |
Resumo(s): | The microfluidic manipulation of hydrogels is a powerful tool to recapitulate functional biological ar- chitectures. A wide range of flow configurations and chip designs have been employed to create mi- crofibers with increasingly complex shapes and compositions requiring individually engineered setups. Distinctly, we demonstrate how one single 3D hydrodynamic flow-focusing chip can be used to obtain a continuous flow of hydrogel precursors, which rearrange themselves based on viscosity and applied pressures. These can crosslink into fibers with a variety of new multi-compartment shapes down to yet- unreported minimal dimensions. To prove the potential of 3D flow-focusing for the biofabrication of com- plex, multi-compartment structures, we tuned material properties and flow conditions to obtain ribbon- like cancer/basement-membrane/stroma models; core-shell vascular-like structures and networks; and multi-chemistry fibers integrating stem cells, biomaterials, and pro-differentiation hydrophobic molecule depots. This innovative biofabrication method can be valuable for the recreation of a broad range of com- plex biological architectures and micro-modeling of distinct 3D environments. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/74754 |
DOI: | 10.1016/j.apmt.2021.101013 |
ISSN: | 2352-9407 |
Versão da editora: | https://doi.org/10.1016/j.apmt.2021.101013 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
20622-2021-flowfocusing-apmt.pdf | 2,34 MB | Adobe PDF | Ver/Abrir |