Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74709
Título: | Recent approaches towards bone tissue engineering |
Autor(es): | Maia, F. Raquel Bastos, Ana Raquel Fernandes Oliveira, J. M. Correlo, V. M. Reis, R. L. |
Palavras-chave: | 3D bioprinting 3D printing Bone tissue engineering Scaffolds Spheroids Vascularized strategies |
Data: | Fev-2022 |
Editora: | Elsevier 1 |
Revista: | Bone |
Citação: | Maia F. R., Bastos A. R., Oliveira J. M., Correlo V.M., Reis R. L. Recent approaches towards bone tissue engineering, Bone, doi:10.1016/j.bone.2021.116256, 2021 |
Resumo(s): | Bone tissue engineering approaches have evolved towards addressing the challenges of tissue mimetic requirements over the years. Different strategies have been combining scaffolds, cells, and biologically active cues using a wide range of fabrication techniques, envisioning the mimicry of bone tissue. On the one hand, biomimetic scaffold-based strategies have been pursuing different biomaterials to produce scaffolds, combining with diverse and innovative fabrication strategies to mimic bone tissue better, surpassing bone grafts. On the other hand, biomimetic scaffold-free approaches mainly foresee replicating endochondral ossification, replacing hyaline cartilage with new bone. Finally, since bone tissue is highly vascularized, new strategies focused on developing pre-vascularized scaffolds or pre-vascularized cellular aggregates have been a motif of study. The recent biomimetic scaffold-based and scaffold-free approaches in bone tissue engineering, focusing on materials and fabrication methods used, are overviewed herein. The biomimetic vascularized approaches are also discussed, namely the development of pre-vascularized scaffolds and pre-vascularized cellular aggregates. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/74709 |
DOI: | 10.1016/j.bone.2021.116256 |
ISSN: | 8756-3282 |
Versão da editora: | https://doi.org/10.1016/j.bone.2021.116256 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
20615-1-s20-s8756328221004221-main.pdf | 7,11 MB | Adobe PDF | Ver/Abrir |