Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74518
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Cano, Amanda | por |
dc.contributor.author | Fonseca, Elena | por |
dc.contributor.author | Ettcheto, Miren | por |
dc.contributor.author | Sánchez-López, Elena | por |
dc.contributor.author | de Rojas, Itziar | por |
dc.contributor.author | Alonso-Lana, Silvia | por |
dc.contributor.author | Morató, Xavier | por |
dc.contributor.author | Souto, Eliana B. | por |
dc.contributor.author | Toledo, Manuel | por |
dc.contributor.author | Boada, Mercè | por |
dc.contributor.author | Marquié, Marta | por |
dc.contributor.author | Ruíz, Agustín | por |
dc.date.accessioned | 2021-10-26T09:11:56Z | - |
dc.date.available | 2021-10-26T09:11:56Z | - |
dc.date.issued | 2021-10-18 | - |
dc.date.submitted | 2021-09 | - |
dc.identifier.citation | Cano, Amanda; Fonseca, Elena; Ettcheto, Miren; Sánchez-López, Elena; de Rojas, Itziar; Alonso-Lana, Silvia; Morató, Xavier; Souto, Eliana; Toledo, Manuel; Boada, Mercè; Marquié, Marta; Ruíz, Agustín, Epilepsy in neurodegenerative diseases: related drugs and molecular pathways. Pharmaceuticals, 14(10), 1057, 2021 | por |
dc.identifier.uri | https://hdl.handle.net/1822/74518 | - |
dc.description.abstract | Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. It is the second most prevalent neurological disease, with 50 million people affected around the world, and 30% of all epilepsies do not respond to available treatments. Currently, the main hypothesis about the molecular processes that trigger epileptic seizures and promote the neurotoxic effects that lead to cell death focuses on the exacerbation of the glutamate pathway and the massive influx of Ca2+ into neurons by different factors. However, other mechanisms have been proposed, and most of them have also been described in other neurodegenerative diseases, such as Alzheimers disease, Parkinsons disease, Huntingtons disease, or multiple sclerosis. Interestingly, and mainly because of these common molecular links and the lack of effective treatments for these diseases, some antiseizure drugs have been investigated to evaluate their therapeutic potential in these pathologies. Therefore, in this review, we thoroughly investigate the common molecular pathways between epilepsy and the major neurodegenerative diseases, examine the incidence of epilepsy in these populations, and explore the use of current and innovative antiseizure drugs in the treatment of refractory epilepsy and other neurodegenerative diseases. | por |
dc.description.sponsorship | Acknowledges the support of the Spanish Ministry of Science, Innovation and Universities under the grant Juan de la Cierva (FJC2018-036012-I). Authors acknowledge the support of the Instituto de Salud Carlos III (ISCIII) Acción Estratégica en Salud, integrated into the Spanish National R+D+I Plan and financed by ISCIII Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER “Una manera de hacer Europa”) grant PI17/01474 awarded to M.B. Boada and grant PI19/00335 awarded to M.M.; M.E. acknowledges the support of the Spanish Ministry of Economy and Competitiveness under the project SAF2017- 84283-R, and CIBERNED under project CB06/05/0024. E.B.S. acknowledges the support of the Portuguese Science and Technology Foundation (FCT) for the strategic fund (UIDB/04469/2020). A.R. acknowledges the support of CIBERNED (Instituto de Salud Carlos III (ISCIII)), the EU/EFPIA Innovative Medicines Initiative Joint Undertaking, ADAPTED Grant Nº 115975, from EXIT project, EU Euronanomed3 Program JCT2017 Grant Nº AC17/00100, from PREADAPT project. Joint Program for Neurodegenerative Diseases (JPND) Grant No. AC19/00097, and from grants PI13/02434, PI16/01861 BA19/00020, and PI19/01301. Acción Estratégica en Salud, integrated in the Spanish National RCDCI Plan and financed by Instituto de Salud Carlos III (ISCIII)- Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER—“Una manera de Hacer Europa”), by Fundación bancaria “La Caixa” and Grífols SA (GR@ACE project) | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.rights | openAccess | por |
dc.subject | Epilepsy | por |
dc.subject | Neurodegenerative diseases | por |
dc.subject | Alzheimers disease | por |
dc.subject | Parkinsons disease | por |
dc.subject | Huntingtons disease | por |
dc.subject | Multiple sclerosis | por |
dc.title | Epilepsy in neurodegenerative diseases: related drugs and molecular pathways | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/1424-8247/14/10/1057 | por |
dc.comments | CEB54956 | por |
oaire.citationStartPage | 1057 | por |
oaire.citationIssue | 10 | por |
oaire.citationConferencePlace | Switzerland | - |
oaire.citationVolume | 14 | por |
dc.date.updated | 2021-10-26T08:28:43Z | - |
dc.identifier.eissn | 1424-8247 | por |
dc.identifier.doi | 10.3390/ph14101057 | por |
dc.subject.fos | Ciências Médicas::Biotecnologia Médica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Pharmaceuticals | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54956_1.pdf | 5,08 MB | Adobe PDF | Ver/Abrir |