Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74513
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Campo DC | Valor | Idioma |
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dc.contributor.author | Fernandes, Margarida | por |
dc.contributor.author | Martins, Pedro Libânio Abreu | por |
dc.contributor.author | Correia, Daniela M. | por |
dc.contributor.author | Carvalho, Estela | por |
dc.contributor.author | Gama, F. M. | por |
dc.contributor.author | Vazquez, Manuel | por |
dc.contributor.author | Bran, Cristina | por |
dc.contributor.author | Lanceros-Méndez, S. | por |
dc.date.accessioned | 2021-10-25T11:06:39Z | - |
dc.date.issued | 2021-01-07 | - |
dc.identifier.citation | Fernandes, Margarida; Martins, Pedro; Correia, Daniela M.; Carvalho, Estela; Gama, F. M.; Vazquez, Manuel; Bran, Cristina; Lanceros-Mendez, Senentxu, Magnetoelectric polymer-based nanocomposites with magnetically controlled antimicrobial activity. ACS Applied Bio Materials, 4(1), 559-570, 2021 | por |
dc.identifier.issn | 2576-6422 | por |
dc.identifier.uri | https://hdl.handle.net/1822/74513 | - |
dc.description.abstract | The emergence of antimicrobial resistance is considered a public health problem due to the overuse and misuse of antibiotics which are losing efficacy toward an increasing number of microorganisms. Advanced antimicrobial strategies via development of alternative drugs and materials able to control microbial infections, especially in clinical settings, are urgently needed. In this work, nanocomposite films were developed from the piezoelectric polyvinylidene fluoride (PVDF) polymer, filled with nickel nanowires (NiNws) in an attempt to control and enhance the antimicrobial activity of the materials via applying a magnetic stimulus. The material was achieved through crystallization of PVDF in the electroactive -phase upon incorporation of anisotropic and negatively charged NiNws in the polymeric matrix at a concentration of 1.5 wt %. The nanocomposites have shown to possess certain antimicrobial properties, which could be considerably boosted through the application of a magnetic field. In fact, more than 55% of bacterial growth inhibition was obtained by employing controlled dynamic magnetic conditions for representative Gram-positive and Gram-negative bacteria, compared to only 25% inhibition obtained under static conditions, i.e., without magnetic stimuli application, with the antibiofilm activity clearly improved as well upon dynamic conditions. This work demonstrates a proof-of-concept for materials able to boost on demand their antimicrobial activity and opens the room for applications in novel medical devices with improved control of healthcare-associated infections. | por |
dc.description.sponsorship | The authors thank the FCT-Fundacão para a Ciência e Tecnologia for financial support in the framework of the Strategic Funding UID/FIS/04650/2019 2020 and UID/BIO/04469/2019 and under projects PTDC/BTM-MAT/28237/2017 and PTDC/EMD−EMD/28159/2017. M.M.F., D.M.C., and P.M. thank support from the FCT for grants SFRH/BPD/121464/2016 and SFRH/BPD/121526/2016 and the contract under the Stimulus of Scientific Employment, Individual Support−2017 Call (CEECIND/03975/2017, respectively). The authors acknowledge funding by the Spanish State Research Agency (AEI) and the European Regional Develop ment Fund (ERFD) through project PID2019-106099RB C43/AEI/10.13039/501100011033 and from the Basque Government Industry and Education Department under the ELKARTEK, HAZITEK, and PIBA (PIBA-2018-06) pro grams, respectively. This work has been partly supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) under project MAT2016-76824-C3-1-R and by the Regional Government of Madrid under project S2018/NMT-4321 NANOMAGCOST-CM. | por |
dc.language.iso | eng | por |
dc.publisher | American Chemical Society | por |
dc.relation | UID/FIS/04650/2019 2020 | por |
dc.relation | UID/BIO/04469/2019 | por |
dc.relation | PTDC/BTM-MAT/28237/2017 | por |
dc.relation | PTDC/EMD−EMD/28159/2017 | por |
dc.relation | SFRH/BPD/121464/2016 | por |
dc.relation | SFRH/BPD/121526/2016 | por |
dc.rights | restrictedAccess | por |
dc.subject | magnetoelectric | por |
dc.subject | electroactive environment | por |
dc.subject | nanocomposites | por |
dc.subject | antimicrobial materials on demand | por |
dc.subject | magnetic bioreactor | por |
dc.title | Magnetoelectric polymer-based nanocomposites with magnetically controlled antimicrobial activity | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://pubs.acs.org/journal/aabmcb | por |
dc.comments | CEB54113 | por |
oaire.citationStartPage | 559 | por |
oaire.citationEndPage | 570 | por |
oaire.citationIssue | 1 | por |
oaire.citationConferencePlace | United States | - |
oaire.citationVolume | 4 | por |
dc.date.updated | 2021-10-09T11:45:15Z | - |
dc.identifier.doi | 10.1021/acsabm.0c01125 | por |
dc.date.embargo | 10000-01-01 | - |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | ACS Applied Bio Materials | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54113_1.pdf Acesso restrito! | 7,68 MB | Adobe PDF | Ver/Abrir |