Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74338
Título: | Silver nanoparticles obtained from Brazilian pepper extracts with synergistic anti-microbial effect: production, characterization, hydrogel formulation, cell viability, and in vitro efficacy |
Autor(es): | Oliveira, Daniele M. de Menezes, Diego B. Andrade, Lucas R. Lima, Felipe da C. Hollanda, Luciana Zielinska, Alexandra Sanchez-Lopez, Elena Souto, Eliana B. Severino, Patrícia |
Palavras-chave: | Brazilian pepper Schinus terebinthifolius Raddi silver nanoparticles green synthesis bacterial infections microbial resistance |
Data: | Mai-2021 |
Editora: | Marcel Dekker Inc. |
Revista: | Pharmaceutical Development and Technology |
Citação: | Oliveira, Daniele M. de; Menezes, Diego B.; Andrade, Lucas R.; Lima, Felipe da C.; Hollanda, Luciana; Zielinska, Alexandra; Sanchez-Lopez, Elena; Souto, Eliana; Severino, Patrícia, Silver nanoparticles obtained from Brazilian pepper extracts with synergistic anti-microbial effect: production, characterization, hydrogel formulation, cell viability, and in vitro efficacy. Pharmaceutical Development and Technology, 26(5), 539-548, 2021. DOI: 10.1080/10837450.2021.1898634 |
Resumo(s): | The synthesis of silver nanoparticles using plant extracts is known as a green approach, as it does not require the use of high pressure, energy, high temperature, or toxic chemicals. The approach makes use of plant extracts in a process called bioreduction, which is mediated by enzymes, proteins, amino acids, and metabolites found in bark, seed, and leaf extracts, transforming silver ions into metallic silver. This work aimed at developing silver nanoparticles (AgNPs) from Brazilian pepper, applying this green methodology. Hydroalcoholic extract of leaves of Schinus terebinthifolius Raddi was prepared and its concentration of polyphenols, tannins, and saponins quantified. The produced nanoparticles were characterized by UV-Vis spectroscopy, thermogravimetric analysis (TG), dynamic light scattering (DLS), and zeta potential (ZP). AgNPs were formulated in sodium alginate hydrogels to obtain a nano-based semi-solid formulation for skin application. The obtained silver nanoparticles of mean size between 350 and 450?nm showed no cytotoxicity against L929 mouse fibroblasts within the concentration range of 0.025?mg/mL and 10?mg/mL. Schinus terebinthifolius Raddi was found to enhance microbial inhibition against the tested strains, especially against gram-negative bacteria. Its potential use as an alternative to overcome bacterial resistance can be expected. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/74338 |
DOI: | 10.1080/10837450.2021.1898634 |
ISSN: | 1083-7450 |
Versão da editora: | https://www.tandfonline.com/doi/abs/10.1080/10837450.2021.1898634 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54310_1.pdf Acesso restrito! | 1,47 MB | Adobe PDF | Ver/Abrir |